ArticleHistochemistry and cell biology2016
Galanin regulates blood glucose level in the zebrafish: a morphological and functional study.
Article in Histochemistry and cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Galanin-Mediated Inflammatory Responses in Zebrafish Spinal Cord Regeneration.Molecular neurobiology · 2025Article
- Evaluation of the Antiseizure Activity of Endemic PlantInternational journal of molecular sciences · 2023Article
- Article
- Assessment of resveratrol on diabetes of zebrafish (Journal of diabetes and metabolic disorders · 2022Article
- Protective Role of Galanin during Chemically Induced Inflammation in Zebrafish Larvae.Biology · 2021Article
- Brain-Body Control of Glucose Homeostasis-Insights From Model Organisms.Frontiers in endocrinology · 2021Review
- Article
- In vivo monitoring of intracellular CaIslets · 2018Article
- In focus in HCB.Histochemistry and cell biology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study has demonstrated the galaninergic innervation of the endocrine pancreas including sources of the galaninergic nerve fibers, and the influence of galanin receptor agonists on blood glucose level in the zebrafish. For the first time, a very abundant galaninergic innervation of the endocrine pancreas during development is shown, from the second day post-fertilization to adulthood. The fibers originated from ganglia consisting of galanin-IR, non-adrenergic (non-sensory) neurons located rostrally to the pancreatic tissue. The ganglia were found on the dorsal side of the initial part of the anterior intestinal segment, close to the intestinal branch of the vagus nerve. The galanin-IR neurons did not show immunoreactivity for applied antibodies against tyrosine hydroxylase, choline acetyltransferase, and vesicular acetylcholine transporter. Intraperitoneal injections of galanin analog NAX 5055 resulted in a statistically significant increase in the blood glucose level. Injections of another galanin receptor agonist, galnon, also caused a rise in blood glucose level; however, it was not statistically significant. The present findings suggest that, like in mammals, in the zebrafish galanin is involved in the regulation of blood glucose level. However, further studies are needed to elucidate the exact mechanism of the galanin action.
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