ArticlePLoS computational biology2015
Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 77 citations in OpenAlex.
- Bidirectional Hopf bifurcation control of narrowband gamma oscillations in Parkinson's disease by the corticothalamic system via non-canonical pathways.Journal of computational neuroscience · 2026Article
- The active role of non-synaptic electromagnetic induction in modulating absence epilepsy: a kinetic modeling study.Biological cybernetics · 2026Article
- Dynamic prediction of nonlinear waveform transitions in a thalamo-cortical neural network under a square sensory control.Cognitive neurodynamics · 2024Article
- Striatum is the potential target for treating absence epilepsy: a theoretical evidence.Cognitive neurodynamics · 2024Article
- Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model.Cognitive neurodynamics · 2024Article
- Criticality supports cross-frequency cortical-thalamic information transfer during conscious states.eLife · 2024Article
- Improved control effect of pathological oscillations by using delayed feedback stimulation in neural mass model with pedunculopontine nucleus.Brain and behavior · 2023Article
- Segregation, integration and balance in resting-state brain functional networks associated with bipolar disorder symptoms.Human brain mapping · 2023Article
- Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients.Frontiers in human neuroscience · 2023Article
- Control of epileptic activities in a cortex network of multiple coupled neural populations under electromagnetic induction.Applied mathematics and mechanics · 2023Article
- The adjustment mechanism of the spike and wave discharges in thalamic neurons: a simulation analysis.Cognitive neurodynamics · 2022Article
- Closed-loop controller based on reference signal tracking for absence seizures.Scientific reports · 2022Article
- Regulating absence seizures by tri-phase delay stimulation applied to globus pallidus internal.Applied mathematics and mechanics · 2022Article
- The inhibition mechanism of epilepsy disease in a computational model.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- The therapeutic mechanism of epilepsy seizures in different target areas: Research on a theoretical model.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021Article
- Regulation and control roles of the basal ganglia in the development of absence epileptiform activities.Cognitive neurodynamics · 2020Article
- The effect of external voltage stimulation on absence seizures.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020Article
- Pivotal Role of Subcortical Structures as a Network Hub in Focal Epilepsy: Evidence from Graph Theoretical Analysis Based on Diffusion-Tensor Imaging.Journal of clinical neurology (Seoul, Korea) · 2019Article
- Bistable Firing Pattern in a Neural Network Model.Frontiers in computational neuroscience · 2019Article
- Analytically determining frequency and amplitude of spontaneous alpha oscillation in Jansen's neural mass model using the describing function method.Chinese physics B = Zhongguo wu li B · 2018Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basal ganglia (BG), serving as an intermediate bridge between the cerebral cortex and thalamus, are believed to play crucial roles in controlling absence seizure activities generated by the pathological corticothalamic system. Inspired by recent experiments, here we systematically investigate the contribution of a novel identified GABAergic pallido-cortical pathway, projecting from the globus pallidus externa (GPe) in the BG to the cerebral cortex, to the control of absence seizures. By computational modelling, we find that both increasing the activation of GPe neurons and enhancing the coupling strength of the inhibitory pallido-cortical pathway can suppress the bilaterally synchronous 2-4 Hz spike and wave discharges (SWDs) during absence seizures. Appropriate tuning of several GPe-related pathways may also trigger the SWD suppression, through modulating the activation level of GPe neurons. Furthermore, we show that the previously discovered bidirectional control of absence seizures due to the competition between other two BG output pathways also exists in our established model. Importantly, such bidirectional control is shaped by the coupling strength of this direct GABAergic pallido-cortical pathway. Our work suggests that the novel identified pallido-cortical pathway has a functional role in controlling absence seizures and the presented results might provide testable hypotheses for future experimental studies.
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