Evidence map›Paper›PMID 26496601›Full record

ReviewCell2015

Germinal center selection and the antibody response to influenza.

Gabriel D Victora, Patrick C Wilson

Abstract readReview
In one paragraph

Review in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Trial
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  13. Engineering early memory B-cell-like phenotype in hydrogel-based immune organoids.Journal of biomedical materials research. Part A · 2022
    Article
  14. Article
  15. Article
  16. Bet-hedging in innate and adaptive immune systems.Evolution, medicine, and public health · 2022
    Article
  17. Article
  18. Article
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  20. Struggle within: evolution and ecology of somatic cell populations.Cellular and molecular life sciences : CMLS · 2021
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gabriel D VictoraWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: victora@wi.mit.edu.
Patrick C WilsonDepartment of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PALESE, PETER · 2012 to 2022
$17.6M
Understanding Human B Cell Responses to Influenza to Improve the Influenza U19AI109946 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAVETCH, JEFFREY VICTOR · 2014 to 2018
$9.6M
University of Chicago Autoimmunity Center of ExcellenceU19AI082724 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2009 to 2023
$7.2M
IN VIVO APPROACHES TO DISSECTING B CELL-T CELL COOPERATION IN GERMINAL CENTERSDP5OD012146 · OD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI VICTORA, GABRIEL D · 2012 to 2016
$2.4M
NIAID NIH HHS 1P01AI097092NIAID NIH HHS 1P01AI097092-03NIAID NIH HHS 2U19AI057266-11NIAID NIH HHS HHSN272201400005CNIAID NIH HHS P01 AI097092NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI082724NIAID NIH HHS U19 AI109946NIAID NIH HHS U19AI109946NIH HHS 5DP5OD012146NIH HHS DP5 OD012146PHS HHS HHSN272201400005C
6 · The paper itself

Abstract

In this Minireview, we discuss basic aspects of germinal center biology in the context of immunity to influenza infection and speculate on how the simultaneous evolutionary races of virus and antibody may impact our efforts to design a universal influenza vaccine.

Indexed as

AnimalsAntibody FormationGerminal CenterHumansInfluenza, HumanInfluenza VaccinesInfluenza Vaccines

Identifiers

PMID26496601
PMCPMC4623701

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.