Evidence map›Paper›PMID 26496555›Full record

ArticleAJR. American journal of roentgenology2015

Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study.

Stephen Chan, Jacqueline A Bello, Shlomo Shinnar, Dale C Hesdorffer, Darrell V Lewis, James MacFall, Ruth C Shinnar, William Gomes, Claire Litherland, Yuan Xu and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJR. American journal of roentgenology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. DLG4-related synaptopathy: a new rare brain disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
  11. Review
  12. Genetic Factors Underlying Sudden Infant Death Syndrome.The application of clinical genetics · 2021
    Review
  13. Observational
  14. Article
  15. Review
  16. Article
  17. Hippocampal abnormalities and sudden childhood death.Forensic science, medicine, and pathology · 2016
    Article
  18. Hippocampal abnormalities and sudden childhood death.Forensic science, medicine, and pathology · 2016
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stephen Chan1 Department of Radiology, Harlem Hospital Center, 506 Lenox Ave, New York, NY 10037.
Jacqueline A Bello2 Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Shlomo Shinnar3 Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Dale C Hesdorffer4 Gertrude Sergievsky Center, Columbia University, New York, NY.
Darrell V Lewis5 Department of Pediatrics, Division of Neurology, Duke University Medical Center, Durham, NC.
James MacFall6 Department of Radiology, Duke University Medical Center, Durham, NC.
Ruth C Shinnar3 Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
William Gomes2 Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Claire Litherland4 Gertrude Sergievsky Center, Columbia University, New York, NY.
Yuan Xu5 Department of Pediatrics, Division of Neurology, Duke University Medical Center, Durham, NC.
Douglas R Nordli7 Department of Neurology, Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL.
John M Pellock8 Department of Neurology, Virginia Commonwealth University, Richmond, VA.
L Matthew Frank9 Department of Neurology, Eastern Virginia Medical School, Norfolk, VA.
Solomon L Moshé3 Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Shumei Sun10 International Epilepsy Consortium, Virginia Commonwealth University, Richmond, VA.
FEBSTAT Study Team

Funding

Consequences of Prolonged Febrile Seizures in ChildhoodR01NS043209 · NINDS · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI SHINNAR, SHLOMO · 2003 to 2012
$21.5M
Consequences of Prolonged Febrile Seizures in ChildhoodR37NS043209 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHINNAR, SHLOMO · 2013 to 2019
$11.4M
EPIDEMIOLOGY OF BRAIN ABNORMALITIES IN FEBRILE SEIZURESR01HD036867 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HESDORFFER, DALE C · 1998 to 2002
$1.8M
NICHD NIH HHS R01 HD036867NICHD NIH HHS R01-HD-036867NINDS NIH HHS R01 NS043209NINDS NIH HHS R01-NS-043209NINDS NIH HHS R37 NS043209
6 · The paper itself

Abstract

objectiveHippocampal malrotation is characterized by incomplete hippocampal inversion with a rounded shape and blurred internal architecture. There is still debate about whether hippocampal malrotation has pathologic significance. We present findings from the Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study on the frequency of and risk factors for hippocampal malrotation. SUBJECTS AND

methodsFEBSTAT is a prospective multicenter study investigating the consequences of febrile status epilepticus in childhood. MRI studies of 226 patients with febrile status epilepticus were analyzed visually by two board-certified neuroradiologists blinded to clinical details and were compared with MRI studies of 96 subjects with first simple febrile seizure. Quantitative analysis of hippocampal volume was performed by two independent observers.

resultsHippocampal malrotation was present in 20 of 226 (8.8%) patients with febrile status epilepticus compared with two of 96 (2.1%) control subjects (odds ratio [OR], 4.56; 95% CI, 1.05-19.92). Hippocampal malrotation was exclusively left-sided in 18 of 22 (81.8%) patients and bilateral in the remaining four patients (18.2%). There was no case of exclusively right-sided hippocampal malrotation. Hippocampal malrotation was more common in boys than in girls (OR, 6.1; 95% CI, 1.7-21.5). On quantitative volumetric MRI analysis, the left hippocampal volume was smaller in patients with hippocampal malrotation than in control subjects with simple febrile seizure (p = 0.004), and the right-to-left hippocampal volume ratio was higher in the hippocampal malrotation group than in the simple febrile seizure group (p < 0.001).

conclusionHippocampal malrotation is a developmental malformation that predominantly affects the left hippocampus in male patients and is more frequently found in children with prolonged febrile status epilepticus than in control subjects. These data provide further evidence that hippocampal malrotation represents a pathologic error in brain development rather than a normal variant.

Indexed as

Child, PreschoolFemaleHippocampusHumansImage Interpretation, Computer-AssistedInfantMagnetic Resonance ImagingMaleProspective StudiesRisk FactorsSeizures, FebrileStatus EpilepticusTorsion Abnormalityfebrile seizureshippocampal malrotationMRIstatus epilepticus

Identifiers

PMID26496555
PMCPMC4621774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.