ArticleClinical and experimental immunology2016
Pathogenic T helper type 17 cells contribute to type 1 diabetes independently of interleukin-22.
Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice.Molecular medicine (Cambridge, Mass.) · 2022Article
- Insights in diabetes: Molecular mechanisms-Protectin DX, an anti-inflammatory and a stimulator of inflammation resolution metabolite of docosahexaenoic acid, protects against the development of streptozotocin-induced type 1 and type 2 diabetes mellitus in male Swiss albino mice.Frontiers in endocrinology · 2022Article
- Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications.Biomedicines · 2021Review
- CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.Disease markers · 2021Article
- Epigenetic modulation of selected immune response genes and altered functions of T lymphocytes and macrophages collectively contribute to autoimmune diabetes protection.BBA advances · 2021Article
- Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy?Journal of clinical medicine · 2020Review
- The AHR Signaling Attenuates Autoimmune Responses During the Development of Type 1 Diabetes.Frontiers in immunology · 2020Review
- Cytokines in type 1 diabetes: mechanisms of action and immunotherapeutic targets.Clinical & translational immunology · 2020Review
- Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- IL-17 and limits of success.Cellular immunology · 2019Review
- DPP-4 Inhibition Leads to Decreased Pancreatic Inflammatory Profile and Increased Frequency of Regulatory T Cells in Experimental Type 1 Diabetes.Inflammation · 2019Article
- Level of inflammatory cytokines tumour necrosis factor α, interleukins 12, 23 and 17 in patients with psoriasis in the context of metabolic syndrome.Postepy dermatologii i alergologii · 2019Article
- [Protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review.Journal of advanced research · 2018Review
- TLR-induced secretion of novel cytokine IL-27 is defective in newly diagnosed type-2 diabetic subjects.Cytokine · 2018Article
- Proteins of TNF-α and IL6 Pathways Are Elevated in Serum of Type-1 Diabetes Patients with Microalbuminuria.Frontiers in immunology · 2018Article
- In vivo activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth.Clinical and experimental immunology · 2017Article
- RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.EMBO molecular medicine · 2017Article
- An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort.International journal of obesity (2005) · 2017Article
- Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?Frontiers in endocrinology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We have shown that pathogenic T helper type 17 (Th17) cells differentiated from naive CD4(+) T cells of BDC2·5 T cell receptor transgenic non-obese diabetic (NOD) mice by interleukin (IL)-23 plus IL-6 produce IL-17, IL-22 and induce type 1 diabetes (T1D). Neutralizing interferon (IFN)-γ during the polarization process leads to a significant increase in IL-22 production by these Th17 cells. We also isolated IL-22-producing Th17 cells from the pancreas of wild-type diabetic NOD mice. IL-27 also blocked IL-22 production from diabetogenic Th17 cells. To determine the functional role of IL-22 produced by pathogenic Th17 cells in T1D we neutralized IL-22 in vivo by using anti-IL-22 monoclonal antibody. We found that blocking IL-22 did not alter significantly adoptive transfer of disease by pathogenic Th17 cells. Therefore, IL-22 is not required for T1D pathogenesis. The IL-22Rα receptor for IL-22 however, increased in the pancreas of NOD mice during disease progression and based upon our and other studies we suggest that IL-22 may have a regenerative and protective role in the pancreatic islets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.