ArticleCritical care medicine2016
Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis.
Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Diagnostic Accuracy of MMP-8 and IL-6-Based Point-of-Care Testing to Detect Peritoneal Dialysis-Related Peritonitis: A Single-Center Experience.Diagnostics (Basel, Switzerland) · 2024Article
- Recent advances in novel diagnostic testing for peritoneal dialysis-related peritonitis.Kidney research and clinical practice · 2022Article
- Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model.Science translational medicine · 2019Article
- Review
- Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.Journal of medicinal chemistry · 2017Article
- Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis.Innate immunity · 2017Article
- Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.Scientific reports · 2016Article
- Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.Molecular medicine (Cambridge, Mass.) · 2016Article
- Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Is Matrix Metalloproteinase-8 Activity in the Mucosal Barrier a Requirement for Leakage of Cecal Material in Peritonitis?Critical care medicine · 2016Article
- Prospective Testing and Redesign of a Temporal Biomarker Based Risk Model for Patients With Septic Shock: Implications for Septic Shock Biology.EBioMedicine · 2015Article
- Culture-Negative Peritonitis and the Latest Diagnostic Techniques.Kidney diseases (Basel, Switzerland)Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveInhibition of matrix metalloproteinase-8 improves survival following cecal ligation and puncture in mice, making it a potential therapeutic target. In the current study, we expand our understanding of the role of matrix metalloproteinase-8 in sepsis by using an adoptive transfer approach and alternative sepsis models.
designWe used three different sepsis models: cecal ligation and puncture, cecal slurry, and intestinal implantation. In our first model, adoptive transfer experiments were followed by cecal ligation and puncture to test the hypothesis that matrix metalloproteinase-8-containing myeloid cells are a critical factor in sepsis following cecal ligation and puncture. Our second model, cecal slurry, used intraperitoneal injections of cecal contents to induce polymicrobial peritonitis without tissue compromise in the recipient. Our third model, intestinal implantation, involved ligating and puncturing a cecum from a donor, and then removing the cecum and placing it into the recipient's peritoneal cavity. Clinically, blood samples were drawn from pediatric patients within 24 hours of meeting criteria for septic shock.
settingBasic science laboratory. SUBJECTS: Wild type and genetically modified mice.
interventionsExperimental models of sepsis. MEASUREMENTS AND MAIN
resultsIn our adoptive transfer experiments, matrix metalloproteinase-8 null mice receiving wild-type marrow had a survival advantage when compared with wild-type mice receiving matrix metalloproteinase-8 null marrow, suggesting that matrix metalloproteinase-8-containing myeloid cells are not a critical factor in sepsis following cecal ligation and puncture. In our cecal slurry model, no survival advantage was seen among matrix metalloproteinase-8 null mice. Our third model, intestinal implantation, found that mice receiving matrix metalloproteinase-8 null intestine had a survival advantage when compared with mice receiving wild-type intestine, regardless of recipient genotype. Clinically, median matrix metalloproteinase-8 serum concentrations were higher in patients with sepsis and primary intestinal pathology than in septic patients without primary intestinal pathology.
conclusionsIntestine-derived matrix metalloproteinase-8 is a critical component of septic peritonitis secondary to intestinal compromise.
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