ArticlePloS one2015
Heterogeneity in the Infection Biology of Campylobacter jejuni Isolates in Three Infection Models Reveals an Invasive and Virulent Phenotype in a ST21 Isolate from Poultry.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Campylobacter jejuni strains isolated in Brazil have important virulence related genes and survive to different stress conditions.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Caecal microbiome transplant inhibits transmission and intestinal colonisation ofPoultry science and management · 2026Article
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- Small worms big discoveries:Frontiers in cellular and infection microbiology · 2025Review
- In vitro investigations on interference of selected probiotic candidates with Campylobacter jejuni adhesion and invasion of primary chicken derived cecal and Caco-2 cells.Gut pathogens · 2024Article
- Characterizing the gut microbiome of broilers raised under conventional and no antibiotics ever practices.Poultry science · 2023Article
- Intestinal Colonization ofMicroorganisms · 2023Article
- The Use of Interdisciplinary Approaches to Understand the Biology ofMicroorganisms · 2022Review
- Quantitative detection and genetic characterization of thermotolerantFrontiers in microbiology · 2022Article
- Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.Communications biology · 2021Article
- Comparison of the Pathogenic Potential ofPathogens (Basel, Switzerland) · 2020Article
- Phage Biocontrol ofFrontiers in microbiology · 2019Article
- Prebiotic Driven Increases in IL-17A Do Not PreventFrontiers in microbiology · 2019Article
- Proximity to Other Commercial Turkey Farms Affects Colonization Onset, Genotypes, and Antimicrobial Resistance Profiles of Campylobacter spp. in Turkeys: Suggestive Evidence from a Paired-Farm Model.Applied and environmental microbiology · 2018Article
- CapC, a Novel Autotransporter and Virulence Factor of Campylobacter jejuni.Applied and environmental microbiology · 2018Article
- The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens.Microbiome · 2018Article
- Comprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity forFrontiers in microbiology · 2018Article
- Feed Choice Led to Higher Protein Intake in Broiler Chickens Experimentally Infected WithFrontiers in nutrition · 2018Article
- Article
- The Bacterial SpeciesFrontiers in microbiology · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although Campylobacter is the leading cause of bacterial foodborne gastroenteritis in the world and the importance of poultry as a source of infection is well understood we know relatively little about its infection biology in the broiler chicken. Much of what we know about the biology of Campylobacter jejuni is based on infection of inbred or SPF laboratory lines of chickens with a small number of isolates used in most laboratory studies. Recently we have shown that both the host response and microbial ecology of C. jejuni in the broiler chicken varies with both the host-type and significantly between C. jejuni isolates. Here we describe heterogeneity in infection within a panel of C. jejuni isolates in two broiler chicken breeds, human intestinal epithelial cells and the Galleria insect model of virulence. All C. jejuni isolates colonised the chicken caeca, though colonisation of other parts of the gastrointestinal tract varied between isolates. Extra-intestinal spread to the liver varied between isolates and bird breed but a poultry isolate 13126 (sequence type 21) showed the greatest levels of extra-intestinal spread to the liver in both broiler breeds with over 70% of birds of the fast growing breed and 50% of the slower growing breed having C. jejuni in their livers. Crucially 13126 is significantly more invasive than other isolates in human intestinal epithelial cells and gave the highest mortality in the Galleria infection model. Taken together our findings suggest that not only is there considerable heterogeneity in the infection biology of C. jejuni in avian, mammalian and alternative models, but that some isolates have an invasive and virulent phenotype. Isolates with an invasive phenotype would pose a significant risk and increased difficulty in control in chicken production and coupled with the virulent phenotype seen in 13126 could be an increased risk to public health.
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