Observational studyMedicine2015
Effect of Hypovitaminosis D on Postoperative Pain Outcomes and Short-Term Health-Related Quality of Life After Knee Arthroplasty: A Cohort Study.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Trial
- Article
- Association of Vitamin D Deficiency With Adverse Postoperative Outcomes Following Hallux Valgus Correction.Foot & ankle orthopaedics · 2026Article
- Role of vitamin D in the management of chronic pain after gastrointestinal surgery.World journal of gastrointestinal surgery · 2025Review
- The role of vitamin D in shoulder health: a comprehensive review of its impact on rotator cuff tears and surgical results.Clinics in shoulder and elbow · 2025Article
- Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.Malaysian orthopaedic journal · 2024Article
- The effect of vitamin D insufficiency on outcomes and complication rates after shoulder arthroplasty: a single center retrospective examination.Seminars in arthroplasty · 2024Article
- Serum vitamin D le Serum vitamin D levels are associated with acute post e associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystect cholecystectomy: a str omy: a strobe compliant pr obe compliant prospectiv ospective obser e observational ational study.Turkish journal of medical sciences · 2023Observational
- The effect of vitamin D supplementation on outcomes following total hip or knee arthroplasty surgery: a rapid systematic review of current evidence.EFORT open reviews · 2022Review
- The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology-a narrative overview of the literature.Annals of translational medicine · 2021Review
- Vitamin D deficiency and total shoulder arthroplasty complications.Shoulder & elbow · 2021Article
- Perioperative Serum 25-Hydroxyvitamin D Levels as a Predictor of Postoperative Opioid Use and Opioid Use Disorder: a Cohort Study.Journal of general internal medicine · 2020Article
- The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review.Patient related outcome measures · 2020Review
- Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis.Orthopaedic journal of sports medicine · 2017Review
- Is there an association between low serum 25-OH-D levels and the length of hospital stay in orthopaedic patients after arthroplasty?Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2016Observational
- Determinants of pain in patients with symptomatic knee osteoarthritis.Caspian journal of internal medicine · 2016Review
- Hypovitaminosis D in lower extremity Joint Arthroplasty: A systematic review and meta-analysis.Journal of orthopaedicsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D may have an important role in pain perception. Inadequate vitamin D levels are associated with suboptimal recovery after surgery. However, the effects of hypovitaminosis D on postoperative pain-related outcomes and its impact on health-related quality of life after surgery are not well understood. The objective of this study was to determine the effects of hypovitaminosis D on postoperative pain-related outcomes and health-related quality of life at 3 months after knee arthroplasty.This was a longitudinal cohort study of 191 consecutive Hong Kong Chinese patients who were given patient-controlled morphine analgesia for up to 72 hours after 214 knee arthroplasties. Serum total 25-hydroxyvitamin D (25-OHD) concentration was assessed by liquid chromatography-tandem mass spectrometry. The primary outcomes were postoperative pain intensity at rest scores (0-72 h), Western Ontario and McMaster Universities (WOMAC) osteoarthritis index (pain, stiffness and function), and moderate-to-severe persistent pain (transformed WOMAC pain score of 0-75 at 3 months after knee arthroplasty; 0, extreme pain; 100, no pain). Group differences were analyzed using generalized estimating equation models and a logistic regression model.The prevalence of preoperative hypovitaminosis D (25-OHD <50 nmol/L) was 44% (95% confidence interval [CI]: 37%-51%). There were transient higher pain intensity scores in the moderate-to-severe hypovitaminosis D (25-OHD <30 nmol/L) group compared with the sufficient vitamin D group. Vitamin D status had no effect on total WOMAC index (P = 0.22). The incidence of moderate-to-severe persistent pain was 9% (95% CI: 6%-14%). Hypovitaminosis D increased the risk of moderate-to-severe persistent pain (adjusted odds ratio 2.64, 95% CI: 1.03-6.77).Preoperative hypovitaminosis D had subtle effects on pain intensity scores in the early postoperative period and is a risk factor for moderate-to-severe persistent pain after knee arthroplasty. Hypovitaminosis D was not associated with worse health-related quality of life at 3 months after knee arthroplasty.
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