Evidence map›Paper›PMID 26496309›Full record

Trial reportMedicine2015

Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial.

Aasmund Avdem Fretland, Andrey Sokolov, Nadya Postriganova, Airazat M Kazaryan, Soren E Pischke, Per H Nilsson, Ingrid Nygren Rognes, Bjorn Atle Bjornbeth, Morten Wang Fagerland, Tom Eirik Mollnes and 1 more

Erratum issued 2 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03131778 nacompletednot on this map

The Inflammatory Response to Stress and Angiogenesis in Open Versus Laparoscopic Liver Resection for Colorectal Liver Metastases

TypeinterventionalSponsorUniversity Hospital, GhentRan2010 to 2011Enrolled40ConditionsLiver Cancer, Colorectal Cancer, Metastatic Cancer, Liver MetastasesArmsLiver resection
NCT04163887 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for Colorectal Liver Metastases: Prospective, Randomized, Controlled Study

TypeinterventionalSponsorInstitut Mutualiste MontsourisRan2021 to 2026Enrolled340ConditionsLiver Metastasis Colon Cancer, Postoperative ComplicationsArmshepatectomy
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  3. [Evidence of minimally invasive oncological surgery of the liver].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
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  6. Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Aasmund Avdem FretlandFrom the Intervention Centre (AAF, NP, AMK, SEP, BE); Department of HPB surgery (AAF, BAB, BE); Department of Immunology, Oslo University Hospital, Oslo (AS, PHN, INR, TEM); Institute of Clinical Medicine (AAF, AMK, BE), University of Oslo, Oslo; Department of Surgery, Finnmark Hospital, Kirkenes (AMK); Division of Emergencies and Critical Care (SEP); Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo (MWF); Research Laboratory, Nordland Hospital, Bodo, and Faculty of Health Sciences, University of Tromso (TEM); and Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway (TEM).
Andrey Sokolov
Nadya Postriganova
Airazat M Kazaryan
Soren E Pischke
Per H Nilsson
Ingrid Nygren Rognes
Bjorn Atle Bjornbeth
Morten Wang Fagerland
Tom Eirik Mollnes
Bjorn Edwin
Ministry of Economic Affairs and Employment · FIOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laparoscopic and open liver resection have not been compared in randomized trials. The aim of the current study was to compare the inflammatory response after laparoscopic and open resection of colorectal liver metastases (CLM) in a randomized controlled trial.This was a predefined exploratory substudy within the Oslo CoMet-study. Forty-five patients with CLM were randomized to laparoscopic (n = 23) or open (n = 22) resection. Ethylenediaminetetraacetic acid-plasma samples were collected preoperatively and at defined time points during and after surgery and snap frozen at -80 C. A total of 25 markers were examined using luminex and enzyme-linked immunosorbent assay techniques: high-mobility box group 1(HMGB-1), cell-free DNA (cfDNA), cytokines, and terminal C5b-9 complement complex complement activation.Eight inflammatory markers increased significantly from baseline: HMGB-1, cfDNA, interleukin (IL)-6, C-reactive protein, macrophage inflammatory protein -1β, monocyte chemotactic protein -1, IL-10, and terminal C5b-9 complement complex. Peak levels were reached at the end of or shortly after surgery. Five markers, HMGB-1, cfDNA, IL-6, C-reactive protein, and macrophage inflammatory protein -1β, showed significantly higher levels in the open surgery group compared with the laparoscopic surgery group.Laparoscopic resection of CLM reduced the inflammatory response compared with open resection. The lower level of HMGB-1 is interesting because of the known association with oncogenesis.

Indexed as

AgedChemokine CCL4Colorectal NeoplasmsComplement Membrane Attack ComplexC-Reactive ProteinFemaleHMGB1 ProteinHumansInflammationInflammation MediatorsLaparoscopyLiver NeoplasmsMaleMiddle AgedChemokine CCL4Complement Membrane Attack ComplexC-Reactive ProteinHMGB1 ProteinHMGB1 protein, humanInflammation Mediators

Identifiers

PMID26496309
PMCPMC4620756
OpenAlexW2293618892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.