ArticleExpert review of proteomics2015
The potential clinical impact of the release of two drafts of the human proteome.
Article in Expert review of proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Origins and Evolution of Human Tandem Duplicated Exon Substitution Events.Genome biology and evolution · 2022Article
- APPRIS principal isoforms and MANE Select transcripts define reference splice variants.Bioinformatics (Oxford, England) · 2022Article
- Assessing the functional relevance of splice isoforms.NAR genomics and bioinformatics · 2021Article
- MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments.Journal of Cancer · 2021Article
- Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation.NAR genomics and bioinformatics · 2020Article
- Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine.Nature biotechnology · 2018Article
- From Molecules to Mechanisms: Functional Proteomics and Its Application to Renal Tubule Physiology.Physiological reviews · 2018Review
- Towards a complete map of the human long non-coding RNA transcriptome.Nature reviews. Genetics · 2018Review
- Article
- Alternative Splicing May Not Be the Key to Proteome Complexity.Trends in biochemical sciences · 2017Review
- The Challenge of Human Spermatozoa Proteome: A Systematic Review.Journal of reproduction & infertilityReview
Corrections and comments
- Comment on
Authors and funding
6 authors.
Funding
Abstract
The authors have carried out an investigation of the two "draft maps of the human proteome" published in 2014 in Nature. The findings include an abundance of poor spectra, low-scoring peptide-spectrum matches and incorrectly identified proteins in both these studies, highlighting clear issues with the application of false discovery rates. This noise means that the claims made by the two papers - the identification of high numbers of protein coding genes, the detection of novel coding regions and the draft tissue maps themselves - should be treated with considerable caution. The authors recommend that clinicians and researchers do not use the unfiltered data from these studies. Despite this these studies will inspire further investigation into tissue-based proteomics. As long as this future work has proper quality controls, it could help produce a consensus map of the human proteome and improve our understanding of the processes that underlie health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.