ArticleOncotarget2015
Association between serum uric acid and bone health in general population: a large and multicentre study.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Analyses of the relationship between hyperuricemia and osteoporosis.Scientific reports · 2021Trial
- Development and validation of a nomogram for predicting low bone mineral density in male patients with ankylosing spondylitis.Frontiers in medicine · 2025Article
- Serum uric acid/creatinine ratio and osteoporosis in the elderly: a NHANES study.Frontiers in medicine · 2025Article
- Article
- Association between serum uric acid level and bone mineral density in men more than 50 years of age.Frontiers in endocrinology · 2023Observational
- Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study.Healthcare (Basel, Switzerland) · 2021Article
- Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970.The Korean journal of internal medicine · 2021Article
- Primary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice With Connexin43 Dominant Negative Mutants.Frontiers in endocrinology · 2021Article
- Osteoporosis in Rheumatic Diseases.International journal of molecular sciences · 2019Review
- Serum Uric Acid Status and Its Association with Bone Mineral Density in the Elderly People Aged 60 Years and More.International journal of endocrinology and metabolism · 2019Article
- Positive association between serum uric acid and bone mineral density in Chinese type 2 diabetes mellitus stratified by gender and BMI.Journal of bone and mineral metabolism · 2018Article
- Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population.Therapeutics and clinical risk management · 2018Article
- Uric acid and bone mineral density in postmenopausal osteoporotic women: the link lies within the fat.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Gout and the Risk of Non-vertebral Fracture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Elevated Serum Uric Acid Is Associated with Greater Bone Mineral Density and Skeletal Muscle Mass in Middle-Aged and Older Adults.PloS one · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies proposed that serum uric acid (UA), an endogenous antioxidant, could be a protective factor against bone loss. However, recently, a study with a population of US adults did not note the protective effects of serum UA. Therefore, the exact association between serum UA and bone health remains unclear. We performed a retrospective consecutive cohort study in a Chinese population to examine the association between serum UA and bone health. This cross-sectional study included 17,735 individuals who underwent lumbar spine bone mineral density (BMD) measurements as part of a health examination. In covariance analyses (multivariable-adjusted), a high serum UA level was associated with a high BMD, T-score, and Z-score. In binary logistic regression analyses (multivariable-adjusted), a high serum UA level was associated with low odds ratios (ORs) for at least osteopenia and osteoporosis in male (age ≥50 years) (OR = 0.72-0.60 and OR = 0.49-0.39, respectively) and postmenopausal female participants (OR = 0.61-0.51 and OR = 0.66-0.49, respectively). In conclusion, serum UA is associated with BMD, the T-score, and the Z-score, and has a strong protective effect against at least osteopenia and osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.