ArticleOncotarget2015
Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Probiotics intervention reduces oxidative stress-driven myocardial injury.Scientific reports · 2025Article
- Unraveling the aging-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence.iScience · 2025Article
- Physical Exercise: A Promising Treatment Against Organ Fibrosis.International journal of molecular sciences · 2025Review
- Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise.JACC. Basic to translational science · 2024Review
- Exercise Training Attenuates Acute β-Adrenergic Receptor Activation-Induced Cardiac Inflammation via the Activation of AMP-Activated Protein Kinase.International journal of molecular sciences · 2023Article
- Exercise renovates HBiogerontology · 2021Article
- Sex-Specific Impacts of Exercise on Cardiovascular Remodeling.Journal of clinical medicine · 2021Review
- Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heartAging · 2021Article
- Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats.Journal of physiology and biochemistry · 2021Article
- The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration.Biomolecules · 2020Review
- Targeting Age-Related Pathways in Heart Failure.Circulation research · 2020Review
- Combination of exercise training and L-arginine reverses aging process through suppression of oxidative stress, inflammation, and apoptosis in the rat heart.Pflugers Archiv : European journal of physiology · 2020Article
- Article
- Moderate aerobic exercise training decreases middle-aged induced pathologic cardiac hypertrophy by improving Klotho expression, MAPK signaling pathway, and oxidative stress status in Wistar rats.Iranian journal of basic medical sciences · 2018Article
- Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies.Oncotarget · 2016Article
- The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms.Circulation research · 2016Review
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is the most important risk factor in cardiovascular disease (CVD), which is the leading causes of death worldwide and the second major cause of death in Taiwan. The major factor in heart failure during aging is heart remodeling, including long-term stress-induced cardiac hypertrophy and fibrosis. Exercise is good for aging heart health, but the impact of exercise training on aging is not defined. This study used 3-, 12- and 18-month-old rats and randomly divided each age group into no exercise training control groups (C3, A12 and A18) and moderate gentle swimming exercise training groups (E3, AE12 and AE18). The protocol of exercise training was swimming five times weekly with gradual increases from the first week from 20 to 60 min for 12 weeks. Analyses of protein from rat heart tissues and sections revealed cardiac inflammation, hypertrophy and fibrosis pathway increases in aged rat groups (A12 and A18), which were improved in exercise training groups (AE12 and AE18). There were no heart injuries in young rat hearts in exercise group E3. These data suggest that moderate swimming exercise training attenuated aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts.
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Registered trials
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