ArticleAnesthesiology2015
Multifrequency Oscillatory Ventilation in the Premature Lung: Effects on Gas Exchange, Mechanics, and Ventilation Distribution.
Article in Anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.Journal of medical devices · 2025Article
- Imaging the Lung in ARDS: A Primer.Respiratory care · 2024Review
- Diseased and healthy murine local lung strains evaluated using digital image correlation.Scientific reports · 2023Article
- Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange.Respiratory research · 2022Article
- Associating local strains to global pressure-volume mouse lung mechanics using digital image correlation.Physiological reports · 2022Article
- Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation.Respiratory research · 2022Article
- Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells.Frontiers in bioengineering and biotechnology · 2022Article
- Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography.Annals of biomedical engineering · 2021Article
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species.Medical image analysis · 2020Article
- Mechanical Ventilation Lessons Learned From Alveolar Micromechanics.Frontiers in physiology · 2020Review
- Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation.Frontiers in physiology · 2020Article
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation.International journal for numerical methods in biomedical engineering · 2019Article
- Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Frequency-Selective Computed Tomography: Applications During Periodic Thoracic Motion.IEEE transactions on medical imaging · 2017Article
- Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Regional gas transport in the heterogeneous lung during oscillatory ventilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDespite the theoretical benefits of high-frequency oscillatory ventilation (HFOV) in preterm infants, systematic reviews of randomized clinical trials do not confirm improved outcomes. The authors hypothesized that oscillating a premature lung with multiple frequencies simultaneously would improve gas exchange compared with traditional single-frequency oscillatory ventilation (SFOV). The goal of this study was to develop a novel method for HFOV, termed "multifrequency oscillatory ventilation" (MFOV), which relies on a broadband flow waveform more suitable for the heterogeneous mechanics of the immature lung.
methodsThirteen intubated preterm lambs were randomly assigned to either SFOV or MFOV for 1 h, followed by crossover to the alternative regimen for 1 h. The SFOV waveform consisted of a pure sinusoidal flow at 5 Hz, whereas the customized MFOV waveform consisted of a 5-Hz fundamental with additional energy at 10 and 15 Hz. Per standardized protocol, mean pressure at airway opening ((Equation is included in full-text article.)) and inspired oxygen fraction were adjusted as needed, and root mean square of the delivered oscillatory volume waveform (Vrms) was adjusted at 15-min intervals. A ventilatory cost function for SFOV and MFOV was defined as (Equation is included in full-text article.), where Wt denotes body weight.
resultsAveraged over all time points, MFOV resulted in significantly lower VC (246.9 ± 6.0 vs. 363.5 ± 15.9 ml mmHg kg) and (Equation is included in full-text article.)(12.8 ± 0.3 vs. 14.1 ± 0.5 cm H2O) compared with SFOV, suggesting more efficient gas exchange and enhanced lung recruitment at lower mean airway pressures.
conclusionOscillation with simultaneous multiple frequencies may be a more efficient ventilator modality in premature lungs compared with traditional single-frequency HFOV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.