ArticlePloS one2015
Worse Health Status and Higher Incidence of Health Disorders in Rhesus Negative Subjects.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Beyond Latency: ChronicBiomedicines · 2025Review
- Relationship Between ABO Blood Groups and Mental Disorders.Journal of blood medicine · 2025Article
- Cognitive Effects ofPathogens (Basel, Switzerland) · 2024Article
- More evidence for widespread antagonistic pleiotropy in polymorphic disease alleles.Frontiers in genetics · 2024Review
- Article
- Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.Genes and immunity · 2022Article
- Redheaded women are more sexually active than other women, but it is probably due to their suitors.Frontiers in psychology · 2022Article
- The importance of being heterozygote: effects of RHD-genotype-sex interaction on the physical and mental health of a non-clinical population.Scientific reports · 2021Article
- Faster life history strategy manifests itself by lower age at menarche, higher sexual desire, and earlier reproduction in people with worse health.Scientific reports · 2021Article
- Rhesus-minus phenotype as a predictor of sexual desire and behavior, wellbeing, mental health, and fecundity.PloS one · 2020Article
- Negative Effects of Latent Toxoplasmosis on Mental Health.Frontiers in psychiatry · 2019Article
- The relation of secondary sex ratio and miscarriage history with Toxoplasma gondii infection.BMC infectious diseases · 2018Article
- Lower performance of Toxoplasma-infected, Rh-negative subjects in the weight holding and hand-grip tests.PloS one · 2018Article
- Health status by gender, hair color, and eye color: Red-haired women are the most divergent.PloS one · 2017Article
- Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhesus-positive and Rhesus-negative persons differ in the presence-absence of highly immunogenic RhD protein on the erythrocyte membrane. The biological function of the RhD molecule is unknown. Its structure suggests that the molecular complex with RhD protein transports NH3 or CO2 molecules across the erythrocyte cell membrane. Some data indicate that RhD positive and RhD negative subjects differ in their tolerance to certain biological factors, including, Toxoplasma infection, aging and fatique. Present cross sectional study performed on 3,130 subjects) showed that Rhesus negative subjects differed in many indices of their health status, including incidences of many disorders. Rhesus negative subjects reported to have more frequent allergic, digestive, heart, hematological, immunity, mental health, and neurological problems. On the population level, a Rhesus-negativity-associated burden could be compensated for, for example, by the heterozygote advantage, but for Rhesus negative subjects this burden represents a serious problem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.