Evidence map›Paper›PMID 26495770›Full record

Trial reportJournal of psychiatric research2015

Side-effects of SSRIs disrupt multimodal treatment for pediatric OCD in a randomized-controlled trial.

Adam M Reid, Joseph P H McNamara, Tanya K Murphy, Andrew G Guzick, Eric A Storch, Wayne K Goodman, Gary R Geffken, Regina Bussing

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.Current problems in pediatric and adolescent health care · 2018
    Review
  13. Article
4 · The record

Corrections and comments

  • Erratum issued
    Goodman, Wayne K [added]
5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Adam M ReidDepartment of Psychiatry, University of Florida, PO Box 100256 1149 Newell Dr., L4-100, Gainesville, FL 32611, USA; Department of Clinical and Health Psychology, University of Florida, 1225 Center Drive, Room 3151, Gainesville, FL 32611, USA; Harvard Medical School, Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. Electronic address: reidam@phhp.ufl.edu.
Joseph P H McNamaraDepartment of Psychiatry, University of Florida, PO Box 100256 1149 Newell Dr., L4-100, Gainesville, FL 32611, USA; Department of Psychology, University of Florida, 2014 Turlington Hall, Gainesville, FL 32611, P.O Box 117300, USA. Electronic address: jpm2@ufl.edu.
Tanya K MurphyDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, 3515 E. Fletcher Ave, Tampa, FL 33613, USA; Department of Pediatrics, University of South Florida, 880 6th Street South, Box 7523, St. Petersburg, FL 33701, USA; All Children's Hospital, John Hopkins Medicine, 600 N Wolfe St # 157, Baltimore, MD 21287, USA. Electronic address: tmurphy@health.usf.edu.
Andrew G GuzickDepartment of Psychiatry, University of Florida, PO Box 100256 1149 Newell Dr., L4-100, Gainesville, FL 32611, USA; Department of Clinical and Health Psychology, University of Florida, 1225 Center Drive, Room 3151, Gainesville, FL 32611, USA. Electronic address: guzick@ufl.edu.
Eric A StorchDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, 3515 E. Fletcher Ave, Tampa, FL 33613, USA; Department of Pediatrics, University of South Florida, 880 6th Street South, Box 7523, St. Petersburg, FL 33701, USA; All Children's Hospital, John Hopkins Medicine, 600 N Wolfe St # 157, Baltimore, MD 21287, USA; Department of Health Policy and Management, University of South Florida, 13201 Bruce B. Downs Blvd., MDC56, Tampa, FL 33612, USA; Rodgers Behavioral Health-Tampa Bay, 2002 N Lois Ave, Tampa, FL 33607, USA. Electronic address: estorch@health.usf.edu.
Wayne K Goodman
Gary R GeffkenDepartment of Psychiatry, University of Florida, PO Box 100256 1149 Newell Dr., L4-100, Gainesville, FL 32611, USA; Department of Clinical and Health Psychology, University of Florida, 1225 Center Drive, Room 3151, Gainesville, FL 32611, USA; Department of Pediatrics, University of Florida, 1600 SW Archer Road, Gainesville, FL 32607, USA. Electronic address: geffken@ufl.edu.
Regina BussingDepartment of Psychiatry, University of Florida, PO Box 100256 1149 Newell Dr., L4-100, Gainesville, FL 32611, USA. Electronic address: rbussing@ufl.edu.
University of Florida · USUniversity of Florida Health · USUniversity of South Florida · USUniversity of South Florida St. Petersburg · US

Funding

SSRI-Induced Activation Syndrome In Pediatric OCDU01MH078594 · NIMH · UNIVERSITY OF FLORIDA · PI BUSSING, REGINA · 2007 to 2010
$928k
NIMH NIH HHS 5UO1 MH078594NIMH NIH HHS U01 MH078594
6 · The paper itself

Abstract

objectiveActivation Syndrome (AS) is a side-effect of antidepressants consisting of irritability, mania, self-harm, akathisia, and disinhibition. The current study was conducted to analyze how AS may hinder treatment outcome for multimodal treatment for children and adolescents with Obsessive-Compulsive Disorder.

methodsFifty-six children or adolescents were recruited at two treatment sites in a double-blind randomized-controlled trial where participants received Cognitive-Behavioral Therapy and were randomized to slow titration of sertraline, regular titration of sertraline or placebo.

resultsUsing a recently developed measure of AS, results suggested that higher average levels of irritability, akathisia, and disinhibition significantly interfered with treatment response and explained 18% of the variance in obsessive-compulsive symptoms during treatment. Interestingly, only session-to-session increases in irritability resulted in a session-to-session increase in obsessive-compulsive symptoms. The observed results were unchanged with the addition of SSRI dosage as a covariate.

conclusionsResults provide empirical support for the proposed hypothesis that AS may hinder multimodal treatment outcome for pediatric OCD. These findings suggest that dosage changes due to AS do not explain why those with higher AS had worse multimodal outcome. Other possible mechanisms explaining this observed disruption are proposed, including how AS may interfere with Cognitive-Behavioral Therapy.

Indexed as

Cognitive Behavioral TherapyAdolescentAkathisia, Drug-InducedChildCombined Modality TherapyDouble-Blind MethodEmotionsFemaleHumansInhibition, PsychologicalMaleModels, StatisticalObsessive-Compulsive DisorderSelective Serotonin Reuptake InhibitorsSertralineTreatment OutcomeSelective Serotonin Reuptake InhibitorsSertralineActivation syndromeChildrenCognitive-behavioral therapyObsessive-Compulsive DisorderSelective serotonin reuptake inhibitorsSide-effects

Identifiers

PMID26495770
PMCPMC4653063
OpenAlexW1956811870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.