ArticleACS chemical neuroscience2016
Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist.
Article in ACS chemical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Light-Regulated Agonists Spatiotemporally Activating the Vitamin D Receptor Mitigate Psoriasis-like Inflammation in Mice without Inducing Hypercalcemia.ACS central science · 2025Article
- Photoisomerization of Azobenzene-Extended Charybdotoxin for the Optical Control of KAngewandte Chemie (International ed. in English) · 2025Article
- A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina.Nature communications · 2025Article
- Combined Liposome-Gold Nanoparticles from Honey: The Catalytic Effect of CassyopeaMolecules (Basel, Switzerland) · 2024Article
- The emergence of molecular systems neuroscience.Molecular brain · 2022Review
- Neuronal firing modulation by a membrane-targeted photoswitch.Nature nanotechnology · 2020Article
- Persistent remodeling and neurodegeneration in late-stage retinal degeneration.Progress in retinal and eye research · 2020Review
- Photopharmacologic Vision Restoration Reduces Pathological Rhythmic Field Potentials in Blind Mouse Retina.Scientific reports · 2019Article
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Restoring Vision to the Blind with Chemical Photoswitches.Chemical reviews · 2018Review
- Light-induced regulation of ligand-gated channel activity.British journal of pharmacology · 2018Review
- Review
- A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling.BMC biology · 2018Article
- Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.Nature communications · 2017Article
- Precise modulation of neuronal activity with synthetic photoswitchable ligands.Current opinion in neurobiology · 2017Review
- A volumetric three-dimensional digital light photoactivatable dye display.Nature communications · 2017Article
- Photopharmacological control of bipolar cells restores visual function in blind mice.The Journal of clinical investigation · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Retinal degenerative diseases can have many possible causes and are currently difficult to treat. As an alternative to therapies that require genetic manipulation or the implantation of electronic devices, photopharmacology has emerged as a viable approach to restore visual responses. Here, we present a new photopharmacological strategy that relies on a photoswitchable excitatory amino acid, ATA. This freely diffusible molecule selectively activates AMPA receptors in a light-dependent fashion. It primarily acts on amacrine and retinal ganglion cells, although a minor effect on bipolar cells has been observed. As such, it complements previous pharmacological approaches based on photochromic channel blockers and increases the potential of photopharmacology in vision restoration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.