ArticleEmergency (Tehran, Iran)2015
Prevalence of Tramadol Consumption in First Seizure Patients; a One-Year Cross-sectional Study.
Article in Emergency (Tehran, Iran), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Harmful Effects of Prescribed Opioids in Children and Adults: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning.Journal of toxicology · 2017Article
- Frequency of Electrocardiographic Abnormalities in Tramadol Poisoned Patients; a Brief Report.Emergency (Tehran, Iran) · 2016Article
- Tramadol side effects: Seizure and hypoglycemia.Anesthesia, essays and researchesArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies have shown that there is a probability of seizure even with therapeutic doses of tramadol. Yet, no accurate data exist regarding this problem in Iran. Therefore, the present study aimed to evaluate the prevalence of tramadol consumption in patients with first seizure referred to the emergency department (ED).
methodsIn the present retrospective one-year cross-sectional study, all patients who were referred to the ED of Poursina Hospital, Rasht, Iran, with the complaint of first seizure were evaluated. Demographic data and data regarding history of tramadol consumption, duration, total dose, last dose, and time passed from the last dose of consumption were recorded and analyzed regarding the study questions using SPSS 20.
results383 (68.9%) out of the 556 patients referred to the ED, were experiencing their first seizure (mean age 26.43 ± 6.48 years; 70.5% male). 84 (21.9%) patients had recently used tramadol. History of seizure in the family of tramadol consumers was significantly lower (3.6% compared to 11%; p = 0.036). Mean total tramadol consumption dose in the last 24 hours was 140.17 ± 73.53 mg (range: 50-300 mg). Duration of tramadol consumption was less than 10 days in 84.5% (df: 2; χ(2) = 96.1; p < 0.001). In addition, 62 (73.8%) patients had seizure within 6 hours of consumption (df: 3; χ(2) = 29.5; p < 0.001).
conclusionResults of the present study showed that 21.9% of the patients with first seizure had a history of tramadol consumption. Seizure following tramadol consumption is more prevalent in the initial 10 days and within 6 hours of consumption. In addition, it seems that lower doses of tramadol may also induce seizure.
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Identifiers
26495407PMC4608351W2127745001What OpenQuestion holds
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