ArticleBioMed research international2015
Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01998204 (Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease
Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Remifentanil requirement for i-gel insertion is reduced in male patients with Parkinson's disease undergoing deep brain stimulator implantation: an up-and-down sequential allocation trial.BMC anesthesiology · 2022Trial
- Minimum Alveolar Concentration-Awake of Sevoflurane is Decreased in Patients with Parkinson's Disease: An Up-and-Down Sequential Allocation Trial.Clinical interventions in aging · 2021Trial
- Comprehensive Review of Anesthetic Strategies for Patients With Neurodegenerative Diseases.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Effects of mild cognitive impairment and sleep disorders on the minimum alveolar concentration value of sevoflurane.BMC anesthesiology · 2024Article
- Globus pallidus externus drives increase in network-wide alpha power with propofol-induced loss-of-consciousness in humans.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Comparison of Half-Effective Concentration of Propofol in Patients with Parkinson's Disease and Non-Parkinson's Disease.Clinical interventions in aging · 2023Article
- Characteristics of Electroencephalogram in the Prefrontal Cortex during Deep Brain Stimulation of Subthalamic Nucleus in Parkinson's Disease under Propofol General Anesthesia.Brain sciences · 2022Article
- Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans.Brain : a journal of neurology · 2019Article
- Propofol Requirement in Patients with Growth Hormone-Secreting Pituitary Tumors Undergoing Transsphenoidal Surgery.Journal of clinical medicine · 2019Article
- High daily caffeine intake is associated with lower propofol requirements for anesthetic induction.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, but whether the neurodegenerative process influences the pharmacodynamics of propofol remains unclear. We aimed to evaluate the effect of PD on pharmacodynamics of propofol. A total of 31 PD patients undergoing surgical treatment (PD group) and 31 pair-controlled non-PD patients undergoing intracranial surgery (NPD group) were recruited to investigate the propofol requirement for unconsciousness induction. Unconsciousness was induced in all patients with target-controlled infusion of propofol. The propofol concentration at which unconsciousness was induced was compared between the two groups. EC50 and EC95 were calculated as well. Demographic data, bispectral index, and hemodynamic values were comparable between PD and NPD groups. The mean target concentration of propofol when unconsciousness was achieved was 2.32 ± 0.38 μg/mL in PD group, which was significantly lower than that in NPD group (2.90 ± 0.35 μg/mL). The EC50 was 2.05 μg/mL (95% CI: 1.85-2.19 μg/mL) in PD group, much lower than the 2.72 μg/mL (95% CI: 2.53-2.88 μg/mL) in NPD group. In conclusion, the effective propofol concentration needed for induction of unconsciousness in 50% of patients is reduced in PD patients. (This trial is registered with NCT01998204.).
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