Evidence map›Paper›PMID 26495241›Full record

ArticleCurrent pulmonology reports2015

MECHANICAL VENTILATION FOR THE LUNG TRANSPLANT RECIPIENT.

Lindsey Barnes, Robert M Reed, Kalpaj R Parekh, Jay K Bhama, Tahuanty Pena, Srinivasan Rajagopal, Gregory A Schmidt, Julia A Klesney-Tait, Michael Eberlein

Open access · greenAbstract read
In one paragraph

Article in Current pulmonology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
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  12. Observational
  13. Article
  14. Review
  15. A Review of Anesthesia for Lung Transplantation.Journal of chest surgery · 2022
    Article
  16. Review
  17. Review
  18. Review
  19. Lung protective ventilation based on donor size is associated with a lower risk of severe primary graft dysfunction after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lindsey BarnesDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics.
Robert M ReedDivision of Pulmonary and Critical Care Medicine, University of Maryland.
Kalpaj R ParekhDepartment of Thoracic and Cardiovascular Surgery, University of Iowa Hospitals and Clinics.
Jay K BhamaDepartment of Thoracic and Cardiovascular Surgery, University of Iowa Hospitals and Clinics.
Tahuanty PenaDivision of Allergy, Pulmonary and Critical Care Medicine, University of Pennsylvania.
Srinivasan RajagopalDepartment of Anesthesia, University of Iowa Hospitals and Clinics.
Gregory A SchmidtDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics.
Julia A Klesney-TaitDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics.
Michael EberleinDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics.
University of Iowa Hospitals and Clinics · USHospital of the University of Pennsylvania · USUniversity of Maryland, College Park · US

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Epithelial Stem Cells in Lung TransplantationK08HL114725 · NHLBI · UNIVERSITY OF IOWA · PI PAREKH, KALPAJ RAJNIKANT · 2012 to 2015
$511k
NHLBI NIH HHS K08 HL114725NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Mechanical ventilation (MV) is an important aspect in the intraoperative and early postoperative management of lung transplant (LTx)-recipients. There are no randomized-controlled trials of LTx-recipient MV strategies; however there are LTx center experiences and international survey studies reported. The main early complication of LTx is primary graft dysfunction (PGD), which is similar to the adult respiratory distress syndrome (ARDS). We aim to summarize information pertinent to LTx-MV, as well as PGD, ARDS, and intraoperative MV and to synthesize these available data into recommendations. Based on the available evidence, we recommend lung-protective MV with low-tidal-volumes (≤6 mL/kg predicted body weight [PBW]) and positive end-expiratory pressure for the LTx-recipient. In our opinion, the MV strategy should be based on donor characteristics (donor PBW as a parameter of actual allograft size), rather than based on recipient characteristics; however this donor-characteristics-based protective MV is based on indirect evidence and requires validation in prospective clinical studies.

Indexed as

acute respiratory distress syndromelung protective ventilationLung transplantationmechanical ventilationprimary graft dysfunctiontidal volumeventilator induced lung injury

Identifiers

PMID26495241
PMCPMC4610154
OpenAlexW2047181642

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.