ArticleJundishapur journal of microbiology2015
Fluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression.
Article in Jundishapur journal of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- The Formulation and Evaluation ofGels (Basel, Switzerland) · 2023Article
- The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections.Frontiers in microbiology · 2022Review
- Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide.Journal of fungi (Basel, Switzerland) · 2021Review
- The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- In vitro anticandidal potency of Syzygium aromaticum (clove) extracts against vaginal candidiasis.BMC complementary medicine and therapies · 2020Article
- Antifungal effect of the effect ofCurrent medical mycology · 2019Article
- Chemical composition and antifungal effect of hydroalcoholic extract ofCurrent medical mycology · 2017Article
- Isolation, molecular identification, and antifungal susceptibility profiles of vaginal isolates ofIranian journal of microbiology · 2016Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome genes may be associated with Candida albicans resistance to azoles. Pir1 gene is described as responsible to induce resistance in C. albicans.
objectivesThe current study aimed to find the relationship between fluconazole resistance and Pir1 protein (Pir1p) overexpression in the females with recurrent C. albicans vaginitis requiring longer fluconazole therapy. PATIENTS AND
methodsA total of 52l vaginal samples were obtained from the females with C. albicans vaginitis. The azole susceptibility phenotype was determined according to the Clinical Laboratory for Standards Institute (CLSI) protocol for disk diffusion method and inhibition zone for fluconazole. Expression of pir1 gene and fluconazole -resistance were evaluated using polymerase chain reaction (PCR) in C. albicans.
resultsIn the 52 isolates, 49 (94%) were resistant to fluconazole. Overexpression of Pir1 gene was detected in 47 (96%) fluconazole-resistant C. albicans isolates.
conclusionsThe findings show fluconazole -resistance in C. albicans isolates with overexpression of Pir1p.
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