ArticleMolecular biology and evolution2016
Adaptive Evolution Is Substantially Impeded by Hill-Robertson Interference in Drosophila.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 89 citations in OpenAlex.
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- Assessing the Presence of Recent Adaptation in the Human Genome With Mixture Density Regression.Genome biology and evolution · 2023Article
- Nascent evolution of recombination rate differences as a consequence of chromosomal rearrangements.PLoS genetics · 2023Article
- Quantifying the fraction of new mutations that are recessive lethal.Evolution; international journal of organic evolution · 2023Article
- Transposable elements maintain genome-wide heterozygosity in inbred populations.Nature communications · 2022Article
- impMKT: the imputed McDonald and Kreitman test, a straightforward correction that significantly increases the evidence of positive selection of the McDonald and Kreitman test at the gene level.G3 (Bethesda, Md.) · 2022Review
- Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen Daphnia magna.Molecular biology and evolution · 2022Article
- Factors That Affect the Rates of Adaptive and Nonadaptive Evolution at the Gene Level in Humans and Chimpanzees.Genome biology and evolution · 2022Article
- Changing Population Size in McDonald-Kreitman Style Analyses: Artifactual Correlations and Adaptive Evolution between Humans and Chimpanzees.Genome biology and evolution · 2022Article
- Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model.Molecular biology and evolution · 2022Article
- Conservation genetics as a management tool: The five best-supported paradigms to assist the management of threatened species.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Recombination Facilitates Adaptive Evolution in Rhizobial Soil Bacteria.Molecular biology and evolution · 2021Article
- Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.Genome biology · 2021Article
- Molecular evolution and the decline of purifying selection with age.Nature communications · 2021Article
- How Good Are Predictions of the Effects of Selective Sweeps on Levels of Neutral Diversity?Genetics · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hill-Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive evolution for any given genome. In this work, we estimate how much HRi impedes the rate of adaptive evolution in the coding genome of Drosophila melanogaster. We compiled a data set of 6,141 autosomal protein-coding genes from Drosophila, from which polymorphism levels in D. melanogaster and divergence out to D. yakuba were estimated. The rate of adaptive evolution was calculated using a derivative of the McDonald-Kreitman test that controls for slightly deleterious mutations. We find that the rate of adaptive amino acid substitution at a given position of the genome is positively correlated to both the rate of recombination and the mutation rate, and negatively correlated to the gene density of the region. These correlations are robust to controlling for each other, for synonymous codon bias and for gene functions related to immune response and testes. We show that HRi diminishes the rate of adaptive evolution by approximately 27%. Interestingly, genes with low mutation rates embedded in gene poor regions lose approximately 17% of their adaptive substitutions whereas genes with high mutation rates embedded in gene rich regions lose approximately 60%. We conclude that HRi hampers the rate of adaptive evolution in Drosophila and that the variation in recombination, mutation, and gene density along the genome affects the HRi effect.
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