ArticleGenes & development2015
Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 75 citations in OpenAlex.
- Transient architecture of the embryonic pancreas determines endocrine mass.Research square · 2026Article
- The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation.Science advances · 2025Article
- LINC MIR503HG Controls SC-β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner.Developmental cell · 2024Article
- NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.Nature communications · 2023Article
- Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish.Science advances · 2023Article
- Epigenetic modulation of cell fate during pancreas development.Trends in developmental biology · 2023Article
- Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions.Development (Cambridge, England) · 2022Article
- The cell cortex as mediator of pancreatic epithelial development and endocrine differentiation.Current opinion in genetics & development · 2022Review
- REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.Genes & development · 2021Article
- Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans.Cell research · 2021Article
- A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.Developmental cell · 2020Article
- Tracing the cellular basis of islet specification in mouse pancreas.Nature communications · 2020Article
- Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro.Molecular metabolism · 2019Article
- A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation.Nature communications · 2019Article
- β-Cell Maturation and Identity in Health and Disease.International journal of molecular sciences · 2019Review
- Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3.Diabetes & metabolism journal · 2019Article
- LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation.PLoS biology · 2019Article
- Modelling the endocrine pancreas in health and disease.Nature reviews. Endocrinology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the mammalian pancreas, endocrine cells undergo lineage allocation upon emergence from a bipotent duct/endocrine progenitor pool, which resides in the "trunk epithelium." Major questions remain regarding how niche environments are organized within this epithelium to coordinate endocrine differentiation with programs of epithelial growth, maturation, and morphogenesis. We used EdU pulse-chase and tissue-reconstruction approaches to analyze how endocrine progenitors and their differentiating progeny are assembled within the trunk as it undergoes remodeling from an irregular plexus of tubules to form the eventual mature, branched ductal arbor. The bulk of endocrine progenitors is maintained in an epithelial "plexus state," which is a transient intermediate during epithelial maturation within which endocrine cell differentiation is continually robust and surprisingly long-lived. Within the plexus, local feedback effects derived from the differentiating and delaminating endocrine cells nonautonomously regulate the flux of endocrine cell birth as well as proliferative growth of the bipotent cell population using Notch-dependent and Notch-independent influences, respectively. These feedback effects in turn maintain the plexus state to ensure prolonged allocation of endocrine cells late into gestation. These findings begin to define a niche-like environment guiding the genesis of the endocrine pancreas and advance current models for how differentiation is coordinated with the growth and morphogenesis of the developing pancreatic epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.