ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016
Obesity and the Incidence of Upper Gastrointestinal Cancers: An Ecological Approach to Examine Differences across Age and Sex.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Impact of Barrett oesophagus diagnoses and endoscopies on oesophageal cancer survival in the UK: A cohort study.Cancer medicine · 2022Article
- DNA methylation markers in esophageal cancer: an emerging tool for cancer surveillance and treatment.American journal of cancer research · 2021Review
- CDK4 Amplification in Esophageal Squamous Cell Carcinoma Associated With Better Patient Outcome.Frontiers in genetics · 2021Article
- Epidemiology of esophageal cancer: update in global trends, etiology and risk factors.Clinical journal of gastroenterology · 2020Review
- The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study.PloS one · 2020Article
- Overweight Patterns Between Childhood and Early Adulthood and Esophageal and Gastric Cardia Adenocarcinoma Risk.Obesity (Silver Spring, Md.) · 2019Article
- Trends and projections in adenocarcinoma and squamous cell carcinoma of the oesophagus in England from 1971 to 2037.British journal of cancer · 2018Article
- Predicting the Future Burden of Esophageal Cancer by Histological Subtype: International Trends in Incidence up to 2030.The American journal of gastroenterology · 2017Article
- Prognostic value of MLH1 promoter methylation in male patients with esophageal squamous cell carcinoma.Oncology letters · 2017Article
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6 authors.
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Abstract
backgroundEsophageal and gastric cancers differ in their epidemiology but have several risk factors in common. The aim of this study was to assess age and sex differences in the burden of esophageal and gastric cancers in the context of the global obesity epidemic.
methodsData from 50 countries were obtained from Cancer Incidence in Five Continents Volume X and GLOBOCAN 2012. Age-specific and age-standardized incidence rates of esophageal adenocarcinoma and squamous cell carcinoma (ESCC), as well as cardia (CGC) and noncardia (NCGC) gastric cancer, were estimated. Countries were grouped and analyzed according to their obesity prevalence.
resultsA gradient across quartiles of obesity prevalence was found for esophageal adenocarcinoma, with the highest incidence rates in high prevalence countries (ASR 3.0 vs. 0.8 per 100,000 in highest vs. lowest obesity quartiles, males). In contrast, for ESCC as well as for CGC and NCGC the reverse was true, with the highest rates observed in countries with the lowest obesity prevalence (ESCC, 2.2 vs. 11.5; CGC, 2.8 vs. 7.8; NCGC, 3.9 vs. 17.4 in highest vs. lowest obesity quartiles, males). Although for esophageal adenocarcinoma, sex and age differences in incidence were most pronounced in countries with a high prevalence of obesity, these differences were much smaller for the other cancer sites assessed.
conclusionsVariation in obesity prevalence may partly explain age and sex differences in the incidence of esophageal adenocarcinomas. IMPACT: Ecologic studies can help assess relationships between risk factors and cancer, and generate new hypotheses that may be pursued through more directed research.
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