ArticleAJNR. American journal of neuroradiology2016
Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Pooled it
- Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest.PloS one · 2018Trial
- Dynamics of infant white matter maturation from birth to 6 months.Communications biology · 2026Article
- Impact of early nutrition on brain development and neurocognitive outcomes in very preterm infants.Pediatric research · 2025Article
- TMagnetic resonance in medicine · 2025Article
- Characterization of language abilities and semantic networks in very preterm children at school-age.PloS one · 2025Article
- Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry.AJNR. American journal of neuroradiology · 2024Article
- Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants.Pediatric radiology · 2024Article
- Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review.Clinical and experimental pediatrics · 2024Article
- The impact of premature birth on auditory-visual processes in very preterm schoolchildren.NPJ science of learning · 2024Article
- Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Characterizing microstructural development in the fetal brain using diffusion MRI from 23 to 36 weeks of gestation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome.Neurobiology of disease · 2023Article
- Development of neonatal-specific sequences for portable ultralow field magnetic resonance brain imaging: a prospective, single-centre, cohort study.EClinicalMedicine · 2023Article
- Human white matter myelinates faster in utero than ex utero.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- In vivo TMagnetic resonance in medicine · 2023Article
- Characterisation of the neonatal brain using myelin-sensitive magnetisation transfer imaging.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Cyto/myeloarchitecture of cortical gray matter and superficial white matter in early neurodevelopment: multimodal MRI study in preterm neonates.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Quantitative MRI Characterization of the Extremely Preterm Brain at Adolescence: Atypical versus Neurotypical Developmental Pathways.Radiology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe alteration of brain maturation in preterm infants contributes to neurodevelopmental disabilities during childhood. Serial imaging allows understanding of the mechanisms leading to dysmaturation in the preterm brain. The purpose of the present study was to provide reference quantitative MR imaging measures across time in preterm infants, by using ADC, fractional anisotropy, and T1 maps obtained by using the magnetization-prepared dual rapid acquisition of gradient echo technique. MATERIALS AND
methodsWe included preterm neonates born at <30 weeks of gestational age without major brain lesions on early cranial sonography and performed 3 MRIs (3T) from birth to term-equivalent age. Multiple measurements (ADC, fractional anisotropy, and T1 relaxation) were performed on each examination in 12 defined white and gray matter ROIs.
resultsWe acquired 107 MRIs (35 early, 33 intermediary, and 39 at term-equivalent age) in 39 cerebral low-risk preterm infants. Measures of T1 relaxation time showed a gradual and significant decrease with time in a region- and hemispheric-specific manner. ADC values showed a similar decline with time, but with more variability than T1 relaxation. An increase of fractional anisotropy values was observed in WM regions and inversely a decrease in the cortex.
conclusionsThe gradual change with time reflects the progressive maturation of the cerebral microstructure in white and gray matter. Our study provides reference trajectories from 25 to 40 weeks of gestation of T1 relaxation, ADC, and fractional anisotropy values in low-risk preterm infants. We speculate that deviation thereof might reflect disturbed cerebral maturation; the correlation of this disturbed maturation with neurodevelopmental outcome remains to be addressed.
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