Evidence map›Paper›PMID 26494476›Full record

ReviewInternational ophthalmology2016

A review of unilateral acute idiopatic maculopathy related to hand-foot-mouth disease with a representative case.

Reşat Duman, Nilay Duman, Bünyamin Kutluksaman, Ersan Çetinkaya, Sibel İnan, Ümit Übeyt İnan

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in International ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Hand, Foot, and Mouth Disease: A Narrative Review.Recent advances in inflammation & allergy drug discovery · 2022
    Review
  5. [Hand, foot and mouth disease-associated maculopathy: a 2-year course].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Reşat DumanDepartment of Ophthalmology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. resatduman@gmail.com.
Nilay DumanDepartment of Dermatology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Bünyamin KutluksamanDepartment of Ophthalmology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Ersan ÇetinkayaDepartment of Ophthalmology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Sibel İnanDepartment of Ophthalmology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Ümit Übeyt İnanDepartment of Ophthalmology, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Afyon Kocatepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to review unilateral acute maculopathy associated with hand-foot-mouth disease with a representative case. Clinical course of a 24-year-old male case with unilateral acute idiopatic maculopathy documented by multimodal imaging is presented, and a review of similar cases is given. On initial examination, best-corrected visual acuity was 20/200 in the left eye. Fundoscopy revealed grayish-yellowish subretinal exudate, and fluorescein angiography demonstrated irregular mottled hyperfluorescence at the central macula. Spectral domain optical coherence tomography demonstrated disruption of ellipsoid layer, which partially resolved on follow-up examinations. Best-corrected visual acuity increased to 20/20 at 3 months, with persistent retinal changes, and mild disruption of ellipsoid layer and persistent mild metamorphopsia. Although hand-foot-mouth disease is usually benign and self-limited in childhood, it may be rarely associated with unilateral vision loss due to maculopathy, especially at early adulthood in both sexes. Vision loss associated with this eruption is acute and reversible in most cases, despite some residual pigmentary and scarring changes in all cases and persistent mild visual loss in some cases. Exact pathophysiology, the causes of variability of clinical features, adulthood onset, unilateral involvement, and role of multimodal imaging are issues which need to be clarified with further research.

Indexed as

Eye Infections, ViralHand, Foot and Mouth DiseaseHumansMacula LuteaMaleRetinal DiseasesVision DisordersYoung AdultAcute maculopathyHand–foot–mouth diseaseUnilateral vision lossViral eruption

Identifiers

PMID26494476
OpenAlexW2131269603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.