ArticleScientific reports2015
Overshoot during phenotypic switching of cancer cell populations.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Granulocyte colony-stimulating factor-producing cutaneous squamous cell carcinoma: A case report and literature review.Medicine · 2025Review
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- Dynamics of a diffusive model for cancer stem cells with time delay in microRNA-differentiated cancer cell interactions and radiotherapy effects.Scientific reports · 2024Article
- Artificial Intelligence for Precision Oncology of Triple-Negative Breast Cancer: Learning from Melanoma.Cancers · 2024Article
- Article
- Memory shapes microbial populations.PLoS computational biology · 2021Article
- The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases.International journal of molecular sciences · 2021Review
- MicroRNA-222 Regulates Melanoma Plasticity.Journal of clinical medicine · 2020Article
- Cancer Stem Cell Plasticity - A Deadly Deal.Frontiers in molecular biosciences · 2020Review
- Cancer stem cells, plasticity, and drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2019Article
- Clonal pattern dynamics in tumor: the concept of cancer stem cells.Scientific reports · 2019Article
- Toward understanding cancer stem cell heterogeneity in the tumor microenvironment.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Systemic Metabolism, Its Regulators, and Cancer: Past Mistakes and Future Potential.Frontiers in endocrinology · 2019Review
- Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention.Molecular cancer · 2017Review
- Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma.Molecular cancer · 2017Review
- ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC.Journal of Cancer · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human melanoma cells using three distinct cancer stem cell (CSC) markers - CXCR6, CD271 and ABCG2 - and observe that the fraction of non-CSC-marked cells first overshoots to a higher level and then returns to the level of unsorted cells. This clearly indicates that the CSC population is homeostatically regulated. Combining experimental measurements with theoretical modeling and numerical simulations, we show that the population dynamics of cancer cells is associated with a complex miRNA network regulating the Wnt and PI3K pathways. Hence phenotypic switching is not stochastic, but is tightly regulated by the balance between positive and negative cells in the population. Reducing the fraction of CSCs below a threshold triggers massive phenotypic switching, suggesting that a therapeutic strategy based on CSC eradication is unlikely to succeed.
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