ReviewNeuron2015
Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry.
Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
204 citing papers in PubMed, 2 syntheses or guidelines pooled it, 384 citations in OpenAlex.
- Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.Psychopharmacology · 2019Pooled it
- Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis.JAMA psychiatry · 2017Pooled it
- Halved Dose of Antipsychotics Versus High-Dose Antipsychotic Therapy for Relapse in Patients with Schizophrenia Receiving High-Dose Antipsychotic Therapy: A Randomized Single-Blind Trial.International journal of molecular sciences · 2025Trial
- In Cocaine Dependence, Neural Prediction Errors During Loss Avoidance Are Increased With Cocaine Deprivation and Predict Drug Use.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.Nature neuroscience · 2026Article
- A Mouse-Tracking Paradigm for Value-Driven Attentional Capture.Behavioral sciences (Basel, Switzerland) · 2026Article
- Initial Drug Sensitivity and Vulnerability to Substance Use Disorders: A Review of Individual Influences.Biology · 2026Review
- Movement Disorder Patients with Depression Have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss.eNeuro · 2026Article
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Assessment of Addictive Behavior in Rats with Partial Knockout of the Dopamine Transporter Gene.International journal of molecular sciences · 2026Article
- Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity.Human brain mapping · 2026Article
- Superior colliculus modulates the compulsion in a model of addiction with foot-shock.Translational psychiatry · 2026Article
- Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.bioRxiv : the preprint server for biology · 2026Article
- Article
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Dopamine signatures of excessive and compulsive cocaine and fentanyl use.bioRxiv : the preprint server for biology · 2026Article
- Reward-associated cues reduce H-current amplitude in midbrain dopamine neurons.Neuropharmacology · 2025Article
144 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Midbrain dopamine (DA) neurons are proposed to signal reward prediction error (RPE), a fundamental parameter in associative learning models. This RPE hypothesis provides a compelling theoretical framework for understanding DA function in reward learning and addiction. New studies support a causal role for DA-mediated RPE activity in promoting learning about natural reward; however, this question has not been explicitly tested in the context of drug addiction. In this review, we integrate theoretical models with experimental findings on the activity of DA systems, and on the causal role of specific neuronal projections and cell types, to provide a circuit-based framework for probing DA-RPE function in addiction. By examining error-encoding DA neurons in the neural network in which they are embedded, hypotheses regarding circuit-level adaptations that possibly contribute to pathological error signaling and addiction can be formulated and tested.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.