Evidence map›Paper›PMID 26494143›Full record

ReviewDrug discovery today2015

Clonotyping for precision oncology.

Ha X Dang, Christopher A Maher

Abstract readReview
In one paragraph

Review in Drug discovery today, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ha X DangMcDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA.
Christopher A MaherMcDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: cmaher@dom.wustl.edu.
James S. McDonnell Foundation · USWashington University in St. Louis · US

Funding

Characterization of Cancer Transcriptomes using Next Generation SequencingR00CA149182 · NCI · WASHINGTON UNIVERSITY · PI MAHER, CHRISTOPHER A · 2011 to 2013
$685k
NCI NIH HHS R00 CA149182
6 · The paper itself

Abstract

Advances in identifying subpopulations of cancer cells and reconstructing the clonal evolution of tumors greatly enhance our understanding of the molecular events within a patient and their context relative to one another. In the rapidly unfolding era of personalized medicine, the ability to monitor clonal dynamics throughout patient care has significant clinical implications for the appropriate development or application of targeted therapies as well as understanding the potential mechanisms driving resistance. In this review, we discuss advances in biotechnology and bioinformatics that improve precision treatment by dissecting clonal evolution, focusing first on the initial discoveries in lymphomas and leukemias followed by the more recent applications to advance our understanding of prostate cancer (PCa).

Indexed as

Computational BiologyHumansMedical OncologyMolecular Targeted TherapyNeoplasmsPrecision Medicine

Identifiers

PMID26494143
PMCPMC4975004
OpenAlexW2114699384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.