ReviewNature reviews. Immunology2015
Resistance and tolerance to foreign elements by prokaryotic immune systems - curating the genome.
Review in Nature reviews. Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- CRISPR-Cas3 and type I restriction-modification team up against blaBMC microbiology · 2024Article
- The making of hypervirulent Klebsiella pneumoniae.Journal of clinical laboratory analysis · 2022Review
- A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13.Cell host & microbe · 2022Article
- The RD2 Pathogenicity Island Modifies the Disease Potential of the Group AInfection and immunity · 2021Article
- Comparative genomic analysis of obligately piezophilicMicrobial genomics · 2021Article
- Review
- From biophysics to 'omics and systems biology.European biophysics journal : EBJ · 2019Review
- Natural tuning of restriction endonuclease synthesis by cluster of rare arginine codons.Scientific reports · 2019Article
- Food Spoilage-Associated Leuconostoc, Lactococcus, and Lactobacillus Species Display Different Survival Strategies in Response to Competition.Applied and environmental microbiology · 2018Article
- The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites.Applied microbiology and biotechnology · 2018Review
- Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts.Nature communications · 2018Article
- Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems.PLoS pathogens · 2017Review
- Article
- Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.Internal medicine review (Washington, D.C. : Online) · 2017Article
- CRISPR-Cas-like system in giant viruses: why MIMIVIRE is not likely to be an adaptive immune system.Virologica Sinica · 2016Article
- Friendly Fire: Biological Functions and Consequences of Chromosomal Targeting by CRISPR-Cas Systems.Journal of bacteriology · 2016Review
- Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense.Trends in microbiology · 2016Review
- Just how Lamarckian is CRISPR-Cas immunity: the continuum of evolvability mechanisms.Biology direct · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To engage in adaptive symbioses or genetic exchange, organisms must interact with foreign, non-self elements despite the risks of predation and parasitism. By surveying the interface between self and non-self, immune systems can help ensure the benevolence of these interactions without isolating their hosts altogether. In this Essay, we examine prokaryotic restriction-modification and CRISPR-Cas (clustered, regularly interspaced palindromic repeat-CRISPR-associated proteins) activities and discuss their analogy to mammalian immune pathways. We further explain how their capacities for resistance and tolerance are optimized to reduce parasitism and immunopathology during encounters with non-self.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.