Evidence map›Paper›PMID 26493792›Full record

Trial reportThe European respiratory journal2016

Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma.

Jun Ma, Peg Strub, Nan Lv, Lan Xiao, Carlos A Camargo, A Sonia Buist, Philip W Lavori, Sandra R Wilson, Kari C Nadeau, Lisa G Rosas

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  7. An Online Weight Loss Intervention for People With Obesity and Poorly Controlled Asthma.The journal of allergy and clinical immunology. In practice · 2022
    Trial
  8. Trial
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  10. Trial
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  12. Trial
  13. Article
  14. Review
  15. Article
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  19. Article
  20. Diet, Asthma, and Severe Asthma Exacerbations in a Prospective Study of Puerto Rican Youth.The journal of allergy and clinical immunology. In practice · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jun MaPalo Alto Medical Foundation Research Institute, Palo Alto, CA, USA Dept of Medicine, Stanford University School of Medicine, Stanford, CA, USA Dept of Health Policy and Administration, University of Illinois at Chicago School of Public Health, Chicago, IL, USA maj2015@uic.edu.
Peg StrubDept of Allergy, Asthma, and Immunology, The Permanente Medical Group, San Francisco Medical Center, San Francisco, CA, USA.
Nan LvPalo Alto Medical Foundation Research Institute, Palo Alto, CA, USA.
Lan XiaoPalo Alto Medical Foundation Research Institute, Palo Alto, CA, USA.
Carlos A CamargoDept of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
A Sonia BuistPulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.
Philip W LavoriDept of Health Research & Policy, Stanford University School of Medicine, Stanford, CA, USA.
Sandra R WilsonPalo Alto Medical Foundation Research Institute, Palo Alto, CA, USA Dept of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Kari C NadeauDept of Paediatric Allergy and Immunology, Stanford University, Stanford, CA, USA.
Lisa G RosasPalo Alto Medical Foundation Research Institute, Palo Alto, CA, USA Dept of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Palo Alto Institute · USStanford University · USMassachusetts General Hospital · USOregon Health & Science University · US

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
A Pilot Study of the DASH Diet in Not-Well-Controlled Adult AsthmaR34HL108753 · NHLBI · PALO ALTO MEDICAL FOUNDATION RES INST · PI MA, JUN · 2012 to 2013
$691k
NCATS NIH HHS UL1 TR001085NCRR NIH HHS UL1 RR025744NHLBI NIH HHS R34 HL108753
6 · The paper itself

Abstract

Rigorous research on the benefit of healthy eating patterns for asthma control is lacking.We randomised 90 adults with objectively confirmed uncontrolled asthma and a low-quality diet (Dietary Approaches to Stop Hypertension (DASH) scores <6 out of 9) to a 6-month DASH behavioural intervention (n=46) or usual-care control (n=44). Intention-to-treat analyses used repeated-measures mixed models.Participants were middle-aged, 67% female and multiethnic. Compared with controls, intervention participants improved on DASH scores (mean change (95% CI) 0.6 (0, 1.1) versus -0.3 (-0.8, 0.2); difference 0.8 (0.2, 1.5)) and the primary outcome, Asthma Control Questionnaire scores (-0.2 (-0.5, 0) versus 0 (-0.3, 0.3); difference -0.2 (-0.5, 0.1)) at 6 months. The mean group differences in changes in Mini Asthma Quality of Life Questionnaire overall and subdomain scores consistently favoured the intervention over the control group: overall 0.4 (95% CI 0, 0.8), symptoms 0.5 (0, 0.9), environment 0.4 (-0.1, 1.0), emotions 0.4 (-0.2, 0.9) and activities 0.3 (0, 0.7). These differences were modest, but potentially clinical significant.The DASH behavioural intervention improved diet quality with promising clinical benefits for better asthma control and functional status among adults with uncontrolled asthma. A full-scale efficacy trial is warranted.

Indexed as

Dietary FiberAdultAnti-Asthmatic AgentsAsthmaBehavior TherapyDiet, Fat-RestrictedDiet, Sodium-RestrictedDisease ProgressionFemaleForced Expiratory VolumeFruitHumansIntention to Treat AnalysisMaleMiddle AgedPilot ProjectsAnti-Asthmatic AgentsDietary Fiber

Identifiers

PMID26493792
PMCPMC5136475
OpenAlexW2175832262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.