ArticleScientific reports2015
Comparison of medetomidine, thiopental and ketamine/midazolam anesthesia in chick embryos for in ovo Magnetic Resonance Imaging free of motion artifacts.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Safety evaluation of a ketamine-dodecyl maltoside combination using angiogenesis and embryonic development models.Scientific reports · 2026Article
- Pharmacokinetics and analgesic efficacy of fentanyl and buprenorphine in chicken embryos.PloS one · 2026Article
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- A Modified Quadrature Birdcage Coil Incorporated With a Curved Feature forIEEE open journal of engineering in medicine and biology · 2024Article
- A fast and simple protocol to anaesthesia in chicken embryos.Experimental animals · 2023Article
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- In-ovo imaging using ostrich eggs: Biomagnetism for detection of cardiac signals and embryonal motion.Experimental biology and medicine (Maywood, N.J.) · 2022Article
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- Effects of 445-nm Laser on Vessels of Chick Chorioallantoic Membrane with Implications to Microlaryngeal Laser Surgery.The Laryngoscope · 2021Article
- Tumor grafts grown on the chicken chorioallantoic membrane are distinctively characterized by MRI under functional gas challenge.Scientific reports · 2020Article
- Novel multimodal MRI and MicroCT imaging approach to quantify angiogenesis and 3D vascular architecture of biomaterials.Scientific reports · 2019Article
- Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases.Molecular imagingArticle
- Evolving applications of the egg: chorioallantoic membrane assay andJournal of tissue engineeringReview
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive assessment of the perfusion capacity of tissue engineered constructs grown on the chorioallantoic membrane by MRI is often hampered by motion artifacts. Therefore, we examined the suitability of three anesthetic regimes for sufficient sedation of the chick embryo. Medetomidine at a dosage of 0.3 mg/kg, was compared to thiopental at 100 mg/kg and ketamine/midazolam at 50 mg/kg and 1 mg/kg, respectively. These soluble anesthetics were applied by dropping a total volume of 0.3 mL onto the surface of the CAM. Motion was videotaped through the window of the eggshell and scored semi-quantitatively. Medetomidine performed best in terms of reduced motion; onset of anesthesia occurred within 10 minutes and for the following 30 minutes, allowing proper in vivo MRI measurements. The other regimen were not sedating deep enough (ketamine/midazolam) and not long enough (thiopental). In sum, medetomidine allows proper sedation for MRI assessment of the perfusion capacity in a tissue engineered construct placed on the CAM.
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