ArticleBMC infectious diseases2015
Feasibility of a birth cohort study dedicated to assessing acute infections using symptom diaries and parental collection of biomaterials.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02654210 (LoewenKIDS - Infections and the Development of the Immune System), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
LoewenKIDS - Infections and the Development of the Immune System
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Feasibility of a hybrid clinical trial for respiratory virus detection in toddlers during the influenza season.BMC medical research methodology · 2021Trial
- The Respiratory Specimen Collection Trial (ReSpeCT): A Randomized Controlled Trial to Compare Quality and Timeliness of Respiratory Sample Collection in the Home by Parents and Healthcare Workers From Children Aged <2 Years.Journal of the Pediatric Infectious Diseases Society · 2020Trial
- Stanford's Outcomes Research in Kids (STORK): a prospective study of healthy pregnant women and their babies in Northern California.BMJ open · 2016Trial
- Real time monitoring of respiratory viral infections in cohort studies using a smartphone app.iScience · 2024Article
- Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol.Frontiers in allergy · 2024Article
- Birth cohort studies using symptom diaries for assessing respiratory diseases-a scoping review.PloS one · 2022Article
- Prospective Study of the Performance of Parent-Collected Nasal and Saliva Swab Samples, Compared with Nurse-Collected Swab Samples, for the Molecular Detection of Respiratory Microorganisms.Microbiology spectrum · 2021Observational
- Cohort Profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood.International journal of epidemiology · 2019Article
- The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study.Stress and health : journal of the International Society for the Investigation of Stress · 2019Article
- Bacterial community structure and effects of picornavirus infection on the anterior nares microbiome in early childhood.BMC microbiology · 2019Article
- Transmission of respiratory and gastrointestinal infections in German households with children attending child care.Epidemiology and infection · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA birth cohort dedicated to studying infections in early childhood may be assisted by parental recording of symptoms on a daily basis and a collection of biomaterials. We aimed at testing the feasibility of this approach for use in a long-term study focusing on infections in children in Germany.
methodsParents of 1- to 3-year-old children (n = 75) were recruited in nursery schools. They were asked to complete a symptom diary on a daily basis and to take monthly and symptom-triggered nasal swabs and stool samples from their child over the study period of three months. Feasibility was measured by means of the return proportions of symptom diaries and bio samples; acceptance was assessed by a questionnaire delivered to participants at the end of the study.
resultsThe majority of the participants filled in the symptom diary during the three months study for 75 or more days (77.3%), and provided the monthly nasal swabs (62.7%) and stool samples (65.3%). The time needed for the tasks was acceptable for most participants (symptom diary: 92.3%, nasal swabs: 98.5%, stool samples: 100.0%). In 64.3% of the symptom-triggered nasal swabs, respiratory viruses were found compared to 55.5% in throat swabs taken by health-care professionals within the "ARE surveillance Lower Saxony", a special project by the Governmental Institute of Public Health of Lower Saxony to investigate causal pathogens for acute respiratory infections in children.
conclusionsThe parental assessment of symptoms and collection of biomaterials in a birth cohort dedicated to studying infections appears feasible in a middle class German population. The success of the study will depend on the ability to maintain these activities over a long time period.
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