ArticleBrain : a journal of neurology2016
Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia.
Article in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Dysconnectivity of Multiple Brain Networks in Schizophrenia: A Meta-Analysis of Resting-State Functional Connectivity.Frontiers in psychiatry · 2019Pooled it
- Neuroanatomical phenotypes in mental illness: identifying convergent and divergent cortical phenotypes across autism, ADHD and schizophrenia.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Dynamic Co-Modulation (DyCoM): A Unified Operator Framework for Dynamic Connectivity in Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- Childhood-Onset Psychosis: A large UK case series.European child & adolescent psychiatry · 2026Article
- Heterogeneity-Aware, Multiscale Annotation of Shared and Specific Neurobiological Signatures among Major Neurodevelopmental Disorders.Research (Washington, D.C.) · 2026Article
- Neuroimmune Clearance and EEG Biomarkers: A Unified Model of ASD and Dyslexia.Neural plasticity · 2026Review
- CCPD under sparsity and low-rank constraints: multi-frequency dynamic functional network connectivity analysis in schizophrenia.Frontiers in neuroscience · 2026Article
- Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder.Science advances · 2025Article
- Metagenome-based characterization of the gut virome in patients with schizophrenia.Journal of translational medicine · 2025Article
- Visualizing functional network connectivity differences using an explainable machine-learning method.Physiological measurement · 2025Article
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Lateralized brain connectivity in auditory verbal hallucinations: fMRI insights into the superior and middle temporal gyri.Frontiers in human neuroscience · 2025Article
- Cross-cohort replicable resting-state functional connectivity in predicting symptoms and cognition of schizophrenia.Human brain mapping · 2024Article
- From periphery immunity to central domain through clinical interview as a new insight on schizophrenia.Scientific reports · 2024Article
- Motion and Form Perception in Childhood-Onset Schizophrenia.Pediatric reports · 2024Article
- Brain network functional connectivity changes in long illness duration chronic schizophrenia.Frontiers in psychiatry · 2024Article
- White matter functional networks in the developing brain.Frontiers in neuroscience · 2024Article
- Altered intrinsic neural activity and its molecular analyses in first-episode schizophrenia with auditory verbal hallucinations.Frontiers in neuroscience · 2024Article
- Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns.BMC medicine · 2023Article
4 more citing papers are in PubMed but not listed here.
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13 authors at 1 institution in 1 country.
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Abstract
Schizophrenia is increasingly recognized as a neurodevelopmental disorder with altered connectivity among brain networks. In the current study we examined large-scale network interactions in childhood-onset schizophrenia, a severe form of the disease with salient genetic and neurobiological abnormalities. Using a data-driven analysis of resting-state functional magnetic resonance imaging fluctuations, we characterized data from 19 patients with schizophrenia and 26 typically developing controls, group matched for age, sex, handedness, and magnitude of head motion during scanning. This approach identified 26 regions with decreased functional correlations in schizophrenia compared to controls. These regions were found to organize into two function-related networks, the first with regions associated with social and higher-level cognitive processing, and the second with regions involved in somatosensory and motor processing. Analyses of across- and within-network regional interactions revealed pronounced across-network decreases in functional connectivity in the schizophrenia group, as well as a set of across-network relationships with overall negative coupling indicating competitive or opponent network dynamics. Critically, across-network decreases in functional connectivity in schizophrenia predicted the severity of positive symptoms in the disorder, such as hallucinations and delusions. By contrast, decreases in functional connectivity within the social-cognitive network of regions predicted the severity of negative symptoms, such as impoverished speech and flattened affect. These results point toward the role that abnormal integration of sensorimotor and social-cognitive processing may play in the pathophysiology and symptomatology of schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.