ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
Effects of catheter-based renal denervation on cardiac sympathetic activity and innervation in patients with resistant hypertension.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05577208 (Cardiac Sympathetic Neuromodulation by Renal Denervation in Hypertrophic Cardiomyopathy), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiac Sympathetic Neuromodulation by Renal Denervation in Hypertrophic Cardiomyopathy (SNYPER Pilot Study)
Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- Renal sympathetic denervation restores aortic distensibility in patients with resistant hypertension: data from a multi-center trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Trial
- Renal denervation improves exercise blood pressure: insights from a randomized, sham-controlled trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Trial
- Reframing renal denervation: from blood pressure reduction to autonomic disease modification-a state-of-the-art review.Clinical hypertension · 2026Review
- Renal denervation for hypertensive heart disease and atrial fibrillation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Skin sodium content as a predictor of blood pressure response to renal denervation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Denervation or stimulation? Role of sympatho-vagal imbalance in HFpEF with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Early Effect of Transcatheter Mitral Valve Repair on Cardiac Sympathetic Nerve Activity.Structural heart : the journal of the Heart Team · 2023Article
- Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats.BMC cardiovascular disorders · 2022Article
- Risk Stratification and Cardiac Sympathetic Activity Assessment Using Myocardial [123I] MIBG Imaging in Renal Denervation.Arquivos brasileiros de cardiologia · 2022Article
- The Sympathetic Nervous System in Hypertension: Roadmap Update of a Long Journey.American journal of hypertension · 2021Article
- Heart failure with preserved ejection fraction based on aging and comorbidities.Journal of translational medicine · 2021Review
- Pulmonary and Systemic Hemodynamics following Multielectrode Radiofrequency Catheter Renal Denervation in Acutely Induced Pulmonary Arterial Hypertension in Swine.BioMed research international · 2021Article
- Renal sympathetic denervation in patients with vasospastic angina.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Expanding the clinical potential of cardiac radionuclide adrenergic imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Review
- Extended Renal Artery Denervation Is Associated with Artery Wall Lesions and Acute Systemic and Pulmonary Hemodynamic Changes: A Sham-Controlled Experimental Study.Cardiovascular therapeutics · 2020Article
- Diagnosis and Management of Patients with Heart Failure with Preserved Ejection Fraction (HFpEF): Current Perspectives and Recommendations.Therapeutics and clinical risk management · 2020Review
- Patient preference for therapies in hypertension: a cross-sectional survey of German patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Effect of renal denervation procedure on left ventricular mass, myocardial strain and diastolic function by CMR on a 12-month follow-up.Japanese journal of radiology · 2019Article
- Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate, whether renal denervation (RDN) has a direct effect on cardiac sympathetic activity and innervation density.
backgroundRDN demonstrated its efficacy not only in reducing blood pressure (BP) in certain patients, but also in decreasing cardiac hypertrophy and arrhythmias. These pleiotropic effects occur partly independent from the observed BP reduction.
methodsEleven patients with resistant hypertension (mean office systolic BP 180 ± 18 mmHg, mean antihypertensive medications 6.0 ± 1.5) underwent I-123-mIBG scintigraphy to exclude pheochromocytoma. We measured cardiac sympathetic innervation and activity before and 9 months after RDN. Cardiac sympathetic innervation was assessed by heart to mediastinum ratio (H/M) and sympathetic activity by wash out ratio (WOR). Effects on office BP, 24 h ambulatory BP monitoring, were documented.
resultsOffice systolic BP and mean ambulatory systolic BP were significantly reduced from 180 to 141 mmHg (p = 0.006) and from 149 to 129 mmHg (p = 0.014), respectively. Cardiac innervation remained unchanged before and after RDN (H/M 2.5 ± 0.5 versus 2.6 ± 0.4, p = 0.285). Cardiac sympathetic activity was significantly reduced by 67 % (WOR decreased from 24.1 ± 12.7 to 7.9 ± 25.3 %, p = 0.047). Both, responders and non-responders experienced a reduction of cardiac sympathetic activity.
conclusionRDN significantly reduced cardiac sympathetic activity thereby demonstrating a direct effect on the heart. These changes occurred independently from BP effects and provide a pathophysiological basis for studies, investigating the potential effect of RDN on arrhythmias and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.