Trial reportClinical research in cardiology : official journal of the German Cardiac Society2016
Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01369186 (Drug Drug Interactions of Antiplatelet Drugs and Morphine), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Drug Drug Interactions of Antiplatelet Drugs and Morphine
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis.Indian heart journalPooled it
- Fentanyl Delays the Platelet Inhibition Effects of Oral Ticagrelor: Full Report of the PACIFY Randomized Clinical Trial.Thrombosis and haemostasis · 2018Trial
- Prasugrel in critically ill patients.Thrombosis and haemostasis · 2017Trial
- Oral P2YEuropean cardiology · 2025Review
- Outcomes of ST-Elevation Myocardial Infarction in Patients With Opioid Dependence: A National Inpatient Sample Study.Cureus · 2024Article
- Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease-Pathophysiology and Translational Therapeutic Approaches.Biomedicines · 2023Review
- Pretreatment with P2YJournal of clinical medicine · 2023Review
- Precision antiplatelet therapy.Research and practice in thrombosis and haemostasis · 2023Article
- P2YFrontiers in cardiovascular medicine · 2022Review
- Influence of METHoxyflurane on ANtiplatelet Effect of ticagrelor in patients with unstable angina pectoris: Rationale and a protocol of a randomized clinical METHANE-SIRIO 4 study.Cardiology journal · 2022Article
- Pre-hospital treatment of patients with acute coronary syndrome: Recommendations for medical emergency teams. Expert position update 2022.Cardiology journal · 2022Article
- Association between pre-hospital chest pain severity and myocardial injury in ST elevation myocardial infarction: A post-hoc analysis of the AVOID study.International journal of cardiology. Heart & vasculature · 2021Article
- Article
- Impact of periprocedural morphine use on mortality in STEMI patients treated with primary PCI.PloS one · 2021Article
- Prehospital opioid dose and myocardial injury in patients with ST elevation myocardial infarction.Open heart · 2020Observational
- Pharmacokinetics and Pharmacodynamics of Approved and Investigational P2Y12 Receptor Antagonists.Clinical pharmacokinetics · 2020Review
- Cardiovascular Complications of Chronic Opium Consumption: A Narrative Review Article.Iranian journal of public health · 2019Review
- In-hospital outcomes in invasively managed acute myocardial infarction patients who receive morphine.Journal of interventional cardiology · 2018Article
- Effect and Safety of Morphine Use in Acute Anterior ST-Segment Elevation Myocardial Infarction.Journal of the American Heart Association · 2018Article
- Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.Journal of pain research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMorphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction.
objectivesTo clarify whether more potent P2Y12-inhibitors may provide an effective alternative, we examined drug-drug interactions between morphine and prasugrel.
methodsTwelve healthy volunteers received 60 mg prasugrel with placebo or 5 mg morphine intravenously in a randomized, double-blind, placebo-controlled, cross-over trial. Pharmacokinetics were determined by liquid chromatography tandem mass spectrometry, and prasugrel effects were measured by platelet function tests.
resultsMorphine neither diminished total drug exposure (AUC), which was the primary endpoint, nor significantly delayed drug absorption of prasugrel. However, morphine reduced maximal plasma concentrations (C max) of prasugrel active metabolite by 31 % (p = 0.019). Morphine slightly, but not significantly, delayed the onset of maximal inhibition of platelet plug formation under high shear rates (30 vs. 20 min). Whole blood aggregation was not influenced.
conclusionsAlthough morphine significantly decreases the maximal plasma concentrations of prasugrel active metabolite, it does not diminish its effects on platelets to a clinically relevant degree in healthy volunteers. However, it should be considered that the observed decrease in C max of prasugrel active metabolite caused by morphine co-administration may gain relevance in STEMI patients. CLINICAL
trial registrationNCT01369186, EUDRA-CT#: 2010-023761-22.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.