ArticleArthritis research & therapy2015
The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma.
Article in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Management of glucocorticoid-induced osteoporosis in rheumatic diseases.Best practice & research. Clinical rheumatology · 2026Review
- Article
- Rethinking fracture "prevalence" and risk stratification in ankylosing spondylitis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Clinical characteristics and management of spinal fractures in patients with ankylosing spondylitis: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Prevalence of Low Bone Density and Fracture Risk Assessed with the FRAX Tool in German Patients with Axial Spondyloarthritis: A Cross-Sectional Study.Life (Basel, Switzerland) · 2026Article
- Risk-stratified management of ankylosing spondylitis-related spinal fractures-a meta-synthesis of contemporary surgical and nonsurgical strategies: a narrative review.Journal of spine surgery (Hong Kong) · 2025Review
- Article
- Emergencies in inflammatory rheumatic diseases.Rheumatology international · 2024Review
- Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis.BMC musculoskeletal disorders · 2023Article
- Service discharges among US Army personnel with selected musculoskeletal and skin conditions: a retrospective cohort study.BMJ open · 2022Article
- The correlation between volumetric bone mineral density and morphological parameters of the proximal femur and clinical outcomes in ankylosing spondylitis patients with hip involvement.BMC musculoskeletal disorders · 2022Article
- Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis-Limited Utility.Journal of clinical medicine · 2021Article
- Vertebral Fractures in Ireland: A Sub-analysis of the DXA HIP Project.Calcified tissue international · 2021Article
- Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients.Scientific reports · 2021Article
- A Contemporary View of the Diagnosis of Osteoporosis in Patients With Axial Spondyloarthritis.Frontiers in medicine · 2020Review
- Acupuncture and Neural Mechanism in the Management of Low Back Pain-An Update.Medicines (Basel, Switzerland) · 2018Review
- [Becoming older with axial spondyloarthritis].Zeitschrift fur Rheumatologie · 2018Review
- Comorbidities in Spondyloarthritis.Frontiers in medicine · 2018Review
- Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study.Arthritis research & therapy · 2017Article
- Thoracic Syndesmophytes Commonly Occur in the Absence of Lumbar Syndesmophytes in Ankylosing Spondylitis: A Computed Tomography Study.The Journal of rheumatology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAn increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture.
methodsWe evaluated the prevalence of VFs (>25% loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma.
resultsForty-six patients (11.8%) had Rx VF (56.4% men, 93.5% in the thoracic spine), and 44.5% had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2% had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (κ 0.90).
conclusionsModerate to severe VFs are found in more than 10% of patients with SpA before the age of 40 years in 5% of women and 9% in men. Most VFs are located in the thoracic region, are related to low femoral neck bone mineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs.
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