ReviewCurrent diabetes reports2015
Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy.
Review in Current diabetes reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Meta-Analysis of Relationship of Sleep Quality and Duration With Risk of Diabetic Retinopathy.Frontiers in endocrinology · 2022Pooled it
- Smart contact lenses: recent advances and future challenges in eye disease diagnosis and treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- The Relationship of Photopic and Mesopic Contrast Sensitivity to Retinal-Choroidal Structural Characteristics in Low-to-Moderate and High Myopia.Translational vision science & technology · 2025Article
- Plant-Derived Exosome-Coated Niosome Oxygen Nanobubbles for the Mitigation of Ocular Ischemia.ACS pharmacology & translational science · 2025Article
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Metabolic reprogramming and interventions in angiogenesis.Journal of advanced research · 2025Review
- Nocturnal hypoxia and age-related macular degeneration.Clinical & experimental ophthalmology · 2024Article
- Investigating the effects of simulated high altitude on colour discrimination.BMJ open ophthalmology · 2024Article
- Additional measures of macular function beyond visual acuity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes: a bioinformatics analysis.International journal of ophthalmology · 2024Article
- Influence of short-term hypoxia exposure on dynamic visual acuity.Frontiers in neuroscience · 2024Article
- Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy.Frontiers in endocrinology · 2024Review
- Factors Associated with Utilization of Teleretinal Imaging in a Hospital-Based Primary Care Setting.Vision (Basel, Switzerland) · 2023Article
- Retinal abnormalities, although relatively common in sleep clinic patients referred for polysomnography, are largely unrelated to sleep-disordered breathing.Sleep & breathing = Schlaf & Atmung · 2023Article
- Keeping an eye on the diabetic foot: The connection between diabetic eye disease and wound healing in the lower extremity.World journal of diabetes · 2022Review
- Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia.Diagnostics (Basel, Switzerland) · 2022Article
- Telehealth Encourages Patients with Diabetes in Racial and Ethnic Minority Groups to Return for in-Person Ophthalmic Care During the COVID-19 Pandemic.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Vision through Healthy Aging Eyes.Vision (Basel, Switzerland) · 2021Review
- Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Utilization of Remote Diabetic Retinal Screening in a Suburban Healthcare System.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In diabetes, retinal blood flow is compromised, and retinal hypoxia is likely to be further intensified during periods of darkness. During dark adaptation, rod photoreceptors in the outer retina are maximally depolarized and continuously release large amounts of the neurotransmitter glutamate-an energetically demanding process that requires the highest oxygen consumption per unit volume of any tissue of the body. In complete darkness, even more oxygen is consumed by the outer retina, producing a steep fall in the retinal oxygen tension curve which reaches a nadir at the depth of the mitochondrial-rich rod inner segments. In contrast to the normal retina, the diabetic retina cannot meet the added metabolic load imposed by the dark-adapted rod photoreceptors; this exacerbates retinal hypoxia and stimulates the overproduction of vascular endothelial growth factor (VEGF). The use of nocturnal illumination to prevent dark adaptation, specifically reducing the rod photoreceptor dark current, should ameliorate diabetic retinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.