ArticleHuman brain mapping2015
Regional specificity of aberrant thalamocortical connectivity in autism.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Comparative analysis of Foxp2 expression in the thalamus of mice, rats, and macaques: implications for the evolution of language circuits.Brain structure & function · 2026Article
- Aperiodic and periodic neural activity during sleep in autism spectrum disorders.BMC medicine · 2026Article
- Abnormal Neuronal Excitability and Reduced Parvalbumin Expression in Shank3-Deficient Parvalbumin Neurons of the Thalamic Reticular Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Linking auditory brain responses to cortical microstructure and sensory behaviors in autism spectrum disorder: a preliminary study.Frontiers in psychiatry · 2026Article
- Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder.Network neuroscience (Cambridge, Mass.) · 2026Article
- Contrast subgraphs catch patterns of altered functional connectivity in autism spectrum disorder.Scientific reports · 2025Article
- Cross-Sectional Mega-Analysis of Resting-State Alterations Associated with Autism and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.Nature. Mental health · 2025Article
- Auditory processing deficits in autism spectrum disorder: mechanisms, animal models, and therapeutic directions.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder.Scientific reports · 2025Article
- Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Atypical co-development of the thalamus and cortex in autism: Evidence from age-related white-gray contrast change.Human brain mapping · 2024Article
- Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Longitudinal Development of Thalamocortical Functional Connectivity in 22q11.2 Deletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Thalamic volume in very preterm infants: associations with severe brain injury and neurodevelopmental outcome at two years.Frontiers in neurology · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Associations between thalamocortical functional connectivity and sensory over-responsivity in infants at high likelihood for ASD.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Increased resting-state thalamocortical functional connectivity in children and young adults with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2023Article
- Sleep Problems in Preschoolers With Autism Spectrum Disorder Are Associated With Sensory Sensitivities and Thalamocortical Overconnectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Thalamic functional connectivity and sensorimotor processing in neurodevelopmental disorders.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Preliminary evidence suggests aberrant (mostly reduced) thalamocortical (TC) connectivity in autism spectrum disorder (ASD), but despite the crucial role of thalamus in sensorimotor functions and its extensive connectivity with cerebral cortex, relevant evidence remains limited. We performed a comprehensive investigation of region-specific TC connectivity in ASD. Resting-state functional MRI and diffusion tensor imaging (DTI) data were acquired for 60 children and adolescents with ASD (ages 7-17 years) and 45 age, sex, and IQ-matched typically developing (TD) participants. We examined intrinsic functional connectivity (iFC) and anatomical connectivity (probabilistic tractography) with thalamus, using 68 unilateral cerebral cortical regions of interest (ROIs). For frontal and parietal lobes, iFC was atypically reduced in the ASD group for supramodal association cortices, but was increased for cingulate gyri and motor cortex. Temporal iFC was characterized by overconnectivity for auditory cortices, but underconnectivity for amygdalae. Occipital iFC was broadly reduced in the ASD group. DTI indices (such as increased radial diffusion) for regions with group differences in iFC further indicated compromised anatomical connectivity, especially for frontal ROIs, in the ASD group. Our findings highlight the regional specificity of aberrant TC connectivity in ASD. Their overall pattern can be largely accounted for by functional overconnectivity with limbic and sensorimotor regions, but underconnectivity with supramodal association cortices. This could be related to comparatively early maturation of limbic and sensorimotor regions in the context of early overgrowth in ASD, at the expense of TC connectivity with later maturing cortical regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.