ReviewPediatric nephrology (Berlin, Germany)2016
Epigenetics mechanisms in renal development.
Review in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Echo characterizes the desynchronization of gene expression and chromatin accessibility during cell-state transitions.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic Regulation in Wilms Tumor.Biomedicines · 2025Review
- Clinical Characteristics and Genetic Variants in Children withMedicina (Kaunas, Lithuania) · 2025Article
- Identification of m6A-associated genes as prognostic and immune-associated biomarkers in Wilms tumor.Discover oncology · 2023Article
- Review
- Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development.International journal of molecular sciences · 2021Article
- Programmed Adult Kidney Disease: Importance of Fetal Environment.Frontiers in physiology · 2020Review
- Towards adulthood with a solitary kidney.Pediatric nephrology (Berlin, Germany) · 2019Review
- Evolution, kidney development, and chronic kidney disease.Seminars in cell & developmental biology · 2019Review
- Modeling epigenetic modifications in renal development and disease with organoids and genome editing.Disease models & mechanisms · 2018Review
- Concepts for a therapeutic prolongation of nephrogenesis in preterm and low-birth-weight babies must correspond to structural-functional properties in the nephrogenic zone.Molecular and cellular pediatrics · 2017Review
- Evolutionary Nephrology.Kidney international reports · 2017Article
- Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism.American journal of physiology. Heart and circulatory physiology · 2017Article
- Renal development in the fetus and premature infant.Seminars in fetal & neonatal medicine · 2017Review
- Fetal first trimester growth is not associated with kidney outcomes in childhood.Pediatric nephrology (Berlin, Germany) · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Appreciation for the role of epigenetic modifications in the diagnosis and treatment of diseases is fast gaining attention. Treatment of chronic kidney disease stemming from diabetes or hypertension as well as Wilms tumor will all profit from knowledge of the changes in the epigenomic landscapes. To do so, it is essential to characterize the epigenomic modifiers and their modifications under normal physiological conditions. The transcription factor Pax2 was identified as a major epigenetic player in the early specification of the kidney. Notably, the progenitors of all nephrons that reside in the cap mesenchyme display a unique bivalent histone signature (expressing repressive epigenetic marks alongside activation marks) on lineage-specific genes. These cells are deemed poised for differentiation and commitment to the nephrogenic lineage. In response to the appropriate inducing signal, these genes lose their repressive histone marks, which allow for their expression in nascent nephron precursors. Such knowledge of the epigenetic landscape and the resultant cell fate or behavior in the developing kidney will greatly improve the overall success in designing regenerative strategies and tissue reprogramming methodologies from pluripotent cells.
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