ArticleBMC neurology2015
Secondary prevention after ischaemic stroke: the ASPIRE-S study.
Article in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Pooled it
- Antithrombotics prescription and adherence among stroke survivors: A systematic review and meta-analysis.Brain and behavior · 2022Pooled it
- Pooled it
- Contemporary achievement of guideline recommendations for blood pressure management after stroke in the CONVINCE trial.European stroke journal · 2026Trial
- The Post-Stroke Checklist: longitudinal use in routine clinical practice during first year after stroke.BMC cardiovascular disorders · 2024Trial
- Trial
- Trial
- Long-term, telephone-based follow-up after stroke and TIA improves risk factors: 36-month results from the randomized controlled NAILED stroke risk factor trial.BMC neurology · 2018Trial
- Follow-Up in Primary Care After Ischemic Stroke - Insights From the Nor-COAST Study.International journal of general medicine · 2025Article
- Factors Influencing Poststroke Cognitive Dysfunction: Cross-Sectional Analysis.JMIR formative research · 2024Article
- Healthcare professional perspectives on medication challenges in the post-stroke patient.Frontiers in pharmacology · 2023Article
- Coverage and equity of essential care services among stroke survivors in the Western Province of Sri Lanka: a community-based cross-sectional study.BMC health services research · 2022Article
- Long-term outcome of a pragmatic trial of multifaceted intervention (STROKE-CARD care) to reduce cardiovascular risk and improve quality-of-life after ischaemic stroke and transient ischaemic attack: study protocol.BMC cardiovascular disorders · 2022Article
- Dyslipidemia in Acute Non-cardioembolic Ischemic Stroke Patients at a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2022Article
- Early Identification, Intervention and Management of Post-stroke Spasticity: Expert Consensus Recommendations.Journal of central nervous system disease · 2021Review
- Risk Stratification in Patients with Ischemic Stroke and Residual Cardiovascular Risk with Current Secondary Prevention.Clinical epidemiology · 2021Article
- Impact of prior stroke on major clinical outcome in chronic kidney disease: the Salford kidney cohort study.BMC nephrology · 2019Article
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort.PloS one · 2019Article
- Surgical treatment and perioperative management of intracranial aneurysms in Chinese patients with ischemic cerebrovascular diseases: a case series.BMC neurology · 2018Article
- Post-stroke hypertension control and receipt of health care services among veterans.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvivors of ischaemic stroke (IS) are at high-risk for future vascular events. Comprehensive information on the adequacy of secondary prevention after IS is lacking despite the knowledge that appropriate secondary prevention improves long-term patient outcomes. ASPIRE-S (Action on Secondary Prevention Interventions and Rehabilitation in Stroke) aimed to prospectively assess secondary prevention in patients 6 months following IS.
methodsConsenting patients admitted with IS to three Dublin hospitals were recruited over 1 year, from October 2011. At 6 months post IS a comprehensive assessment was completed, modelled on the EUROASPIRE protocol for evaluation of the adequacy of secondary prevention in post-discharge cardiac patients. This assessment included measurements of blood pressure, body mass index and fasting lipid and glucose profiles. Secondary preventive medications and smoking status were also documented.
resultsThree hundred two patients (58 % male) participated, of whom 256 (85 %) were followed-up at 6 months. Mean age was 69 years (range 22-95). At follow-up, 68 % of patients had a BMI >25 kg/m(2) and 16.4 % were still smoking. Almost two-thirds (63.4 %) had a blood pressure >140/90 and 23 % had low-density-lipoprotein >2.5 mmol/L. 28 % of diabetic patients had HbA1c ≥ 7 %. Ninety seven percent of patients were on anti-platelet and/or anticoagulant therapy. Of those with atrial fibrillation, 82 % were anti-coagulated (mean INR of 2.4). Ninety-five percent were on lipid-lowering therapy and three-quarters were on anti-hypertensive therapy.
conclusionThis prospective multi-centre survey of IS patients demonstrated a high prevalence of remaining modifiable risk factors at 6 months post stroke, despite the widespread prescription of secondary preventive medications. There is scope to improve preventive measures after IS (in particular blood pressure) by incorporating evidence-based guidelines into quality assurance cycles in stroke care.
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