ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2016
Nonalcoholic Steatohepatitis Is Associated With Increased Mortality in Obese Patients Undergoing Bariatric Surgery.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Human hepatic gene expression signature of non-alcoholic fatty liver disease progression, a meta-analysis.Scientific reports · 2017Pooled it
- Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis.Hepatology (Baltimore, Md.) · 2017Pooled it
- Monitoring of Liver Function Tests after Roux-en-Y Gastric Bypass: An Examination of Evidence Base.Obesity surgery · 2016Pooled it
- Epidemiological and socio-economic burden of MASH (previously known as NASH) in Europe: a systematic literature review.Journal of endocrinological investigation · 2026Review
- A liver gene signature links liver cancer risk in chronic viral hepatitis to intrahepatic IgA plasma cells.JHEP reports : innovation in hepatology · 2026Article
- A Bibliometric Analysis of Bariatric Surgery in Non-alcoholic Fatty Liver Disease: Research Trends and Influential Publications (2000-2024).Obesity surgery · 2026Review
- An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection.Nature communications · 2024Article
- Epidermal Growth Factor Receptor Inhibition With Erlotinib in Liver: Dose De-Escalation Pilot Trial as an Initial Step in a Chemoprevention Strategy.Gastro hep advances · 2024Article
- Nonalcoholic liver disease: Epidemiology, risk factors, natural history, and management strategies.Annals of the New York Academy of Sciences · 2023Review
- Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation.JCI insight · 2022Article
- Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.Science translational medicine · 2022Article
- Molecular Signature Predictive of Long-Term Liver Fibrosis Progression to Inform Antifibrotic Drug Development.Gastroenterology · 2022Article
- Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.BMC endocrine disorders · 2022Review
- Bariatric Surgery in NAFLD.Digestive diseases and sciences · 2022Review
- A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease.Adipocyte · 2021Article
- Liver cell circuits and therapeutic discovery for advanced liver disease and cancer.Comptes rendus biologies · 2021Review
- A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.Nature communications · 2021Article
- Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system.Communications biology · 2021Article
- A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis.Med (New York, N.Y.) · 2021Article
- Individualized treatment options for patients with non-cirrhotic and cirrhotic liver disease.World journal of gastroenterology · 2021Review
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Authors and funding
13 authors.
Funding
Abstract
BACKGROUND &
aimsBariatric surgery is associated with improved outcomes in subjects with severe obesity. We investigated the prognostic relevance of nonalcoholic steatohepatitis (NASH) and liver gene expression patterns in patients undergoing bariatric surgery.
methodsWe performed a retrospective analysis of 492 subjects who underwent gastric bypass bariatric surgery at a single center in Switzerland from January 1997 through December 2004; routine perioperative liver biopsies were collected, analyzed histologically, and RNA was isolated. We collected data on overall survival and clinical and biochemical parameters and compared these with data from propensity score-matched subjects participating in the third National Health and Nutrition Examination Survey (NHANES III). We used liver biopsies to identify bariatric surgery patients with NASH; NHANES III participants with NASH were identified based on a hyperechogenic liver at ultrasound and increased alanine transaminase levels. We analyzed a 32-gene signature associated with NAFLD severity in the liver tissues collected from 47 bariatric surgery patients with NASH, and assessed its prognostic features using nearest template prediction and survival analysis.
resultsAt baseline, the median body mass index of patients who underwent bariatric surgery was 43.6 kg/m
conclusionsHistologically proven NASH is associated with increased risk of death within a median follow-up of 10.2 years after bariatric surgery, compared with patients who undergo bariatric surgery without NASH. The survival benefit of bariatric surgery in subjects with NASH may be reduced. A 32-gene expression pattern identified patients with NASH who underwent bariatric surgery and had shorter survival times.
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