Evidence map›Paper›PMID 26492493›Full record

ArticlePloS one2015

Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis.

Hsing-Fang Lu, Kuo-Sheng Hung, Yu-Wen Hsu, Yu-Ting Tai, Lin-Shan Huang, Yu-Jia Wang, Henry Sung-Ching Wong, Yi-Hsiang Hsu, Wei-Chiao Chang

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hsing-Fang LuDepartment of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan; Department of Pharmacy, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan.
Kuo-Sheng HungDepartment of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Yu-Wen HsuDepartment of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
Yu-Ting TaiDepartment of Anesthesiology, Taipei Medical University, Taipei, Taiwan.
Lin-Shan HuangDepartment of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
Yu-Jia WangDepartment of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
Henry Sung-Ching WongMaster Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Yi-Hsiang HsuBroad Institute of MIT and Harvard, Cambridge, MA, United States of America; Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA, United States of America.
Wei-Chiao ChangDepartment of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAgedBone and BonesBone DensityCase-Control StudiesDemographyFemaleHaplotypesHumansHydroxymethyl and Formyl TransferasesLinkage DisequilibriumMaleOsteoporosisPolymorphism, Single NucleotideRisk FactorsFTCDNL1 protein, humanHydroxymethyl and Formyl Transferases

Identifiers

PMID26492493
PMCPMC4619591
OpenAlexW2147948271

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.