ArticlePLoS neglected tropical diseases2015
The Potential for a Blood Test for Scabies.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Scabies Diagnosis: A Narrative Review of Diagnostic Methods, Clinical Misdiagnosis, and Emerging Directions.Journal of clinical medicine · 2026Review
- Clinical practice guidelines for the diagnosis and treatment of scabies in Korea: Part 1. Epidemiology, clinical manifestations, and diagnosis - a secondary publication.Ewha medical journal · 2024Article
- Scabies vaccines: where we stand and challenges ahead.Parasitology research · 2024Review
- Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection?Parasitology research · 2022Article
- Laboratory-based diagnosis of scabies: a review of the current status.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Review
- Development of a rapid scabies immunodiagnostic assay based on transcriptomic analysis of Sarcoptes scabiei var. nyctereutis.Scientific reports · 2021Article
- Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome.PLoS neglected tropical diseases · 2021Article
- The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies.The British journal of dermatology · 2020Review
- An Antibody Persistent and Protective Two rSsCLP-Based Subunit Cocktail Vaccine againstVaccines · 2020Article
- A review of sarcoptic mange in North American wildlife.International journal for parasitology. Parasites and wildlife · 2019Review
- The public health control of scabies: priorities for research and action.Lancet (London, England) · 2019Review
- Characterizing the growth of Sarcoptes scabiei infrapopulations.Experimental & applied acarology · 2018Article
- APeerJ · 2018Article
- Molecular characteristics and serodiagnostic potential of chitinase-like protein fromOncotarget · 2017Article
- Host immune responses to the itch mite, Sarcoptes scabiei, in humans.Parasites & vectors · 2017Review
- A review of Sarcoptes scabiei: past, present and future.Parasites & vectors · 2017Review
- Identification of antigenic Sarcoptes scabiei proteins for use in a diagnostic test and of non-antigenic proteins that may be immunomodulatory.PLoS neglected tropical diseases · 2017Article
- Laboratory Diagnosis of Scabies Using a Simple Saline Mount: A Clinical Microbiologist's Report.Cureus · 2017Article
- Article
- House Dust Mite Allergens: New Discoveries and Relevance to the Allergic Patient.Current allergy and asthma reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundScabies afflicts millions of people worldwide, but it is very difficult to diagnose by the usual skin scrape test, and a presumptive diagnosis is often made based on clinical signs such as rash and intense itch. A sensitive and specific blood test to detect scabies would allow a physician to quickly make a correct diagnosis.
objectiveOur objective was to profile the mite-specific antibodies present in the sera of patients with ordinary scabies.
methodsSera of 91 patients were screened for Ig, IgD, IgE, IgG and IgM antibodies to S. scabiei, as well as to the house dust mites Dermatophagoides farinae, D. pteronyssinus and Euroglyphus maynei.
results45%, 27% and 2.2% of the patients had measurable amounts of mixed Ig, IgG and IgE that recognized scabies mite antigens. However, 73.6% of the scabies patients had serum IgM that recognized scabies proteins, and all except two of them also had IgM that recognized all of the three species of dust mites. No patient had serum antibody exclusively reactive to scabies mite antigens.
conclusionsCo-sensitization or cross-reactivity between antigens from scabies and house dust mites confounds developing a blood test for scabies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.