ReviewMarine drugs2015
Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses.
Review in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 3 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Pooled it
- Efficacy and Security of Tetrodotoxin in the Treatment of Cancer-Related Pain: Systematic Review and Meta-Analysis.Marine drugs · 2023Pooled it
- Pooled it
- Tetrodotoxin (TTX): What do we currently know? The state of the art.Archives of toxicology · 2026Review
- Epidemiology of Pufferfish Poisoning in Japan: Trends and Insights from 2004 to 2023.JMA journal · 2026Article
- Acute and sub-acute toxicity assessment of tetrodotoxin in Sprague-Dawley rats following intramuscular injection.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Review
- A Review on Climate Change Redefining Tetrodotoxin Accumulation and Ecological Dynamics in Pufferfishes.Marine drugs · 2026Review
- Poison Apple-like Fruit Ingestion: A Case Report and Review of Manchineel Fruit Toxicity.International journal of environmental research and public health · 2026Review
- Pufferfish exposure and presumed tetrodotoxicosis in Australian dogs: 372 cases (2007-2018).Australian veterinary journal · 2026Article
- Envenomations, stings, and traumas caused by marine invertebrates: from scientific facts to a forensic vision towards sustainable health and conservation strategies: a review.Archives of toxicology · 2026Review
- Potential Increase in Known and Emerging Biotoxins in Marine Ecosystem Due to Climate Change and Subsequent Health Issues.Foods (Basel, Switzerland) · 2026Review
- Fatal pufferfish poisoning 1000 km inland: a case series from eastern Turkey.Arhiv za higijenu rada i toksikologiju · 2026Article
- Toxicity Profile of the Oceanic PufferfishMarine drugs · 2026Article
- Gut Epithelium of the Highly Toxic Ribbon WormToxins · 2026Article
- Targeting NaInternational journal of molecular sciences · 2026Review
- A comprehensive study on freshwater pufferfishFrontiers in veterinary science · 2026Article
- Voltage-Gated Sodium Channel Substitutions Underlying Tetrodotoxin Resistance in Nemerteans: Ecological and Evolutionary Implications.International journal of molecular sciences · 2025Article
- A Review of Traditional, Time-Honoured Foods and Recipes: To Choose to Use or Not to Use.Foods (Basel, Switzerland) · 2025Review
- Voltage-gated sodium channels in excitable cells as drug targets.Nature reviews. Drug discovery · 2025Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and fatalities each year. The origin of TTX is unknown, but in the pufferfish, it seems to be produced by endosymbiotic bacteria that often seem to be passed down the food chain. The ingestion of contaminated pufferfish, considered the most delicious fish in Japan, is the usual route of toxicity. This neurotoxin, reported as a threat to human health in Asian countries, has spread to the Pacific and Mediterranean, due to the increase of temperature waters worldwide. TTX, for which there is no known antidote, inhibits sodium channel producing heart failure in many cases and consequently death. In Japan, a regulatory limit of 2 mg eq TTX/kg was established, although the restaurant preparation of "fugu" is strictly controlled by law and only chefs qualified are allowed to prepare the fish. Due to its paralysis effect, this neurotoxin could be used in the medical field as an analgesic to treat some cancer pains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.