SynthesisTransplantation2015
Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation: A Systematic Review and Meta-Analysis.
Synthesis in Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 9 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- AASLD AST Practice Guideline on adult liver transplantation: Candidate evaluation.Hepatology (Baltimore, Md.) · 2026Guideline
- Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Translational psychiatry · 2025Pooled it
- Psychological distress and self-psychological adjustment methods of lung transplant recipients: an overview of systematic reviews.BMC psychology · 2025Pooled it
- Self-reported poor quality of sleep in solid organ transplant: A systematic review.Transplantation reviews (Orlando, Fla.) · 2021Pooled it
- Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies.Molecular psychiatry · 2020Pooled it
- Food insecurity and mental health: a systematic review and meta-analysis.Public health nutrition · 2020Pooled it
- Psychological and Psychopathological Aspects of Kidney Transplantation: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses.BMC medicine · 2018Pooled it
- Anxiety disorders and all-cause mortality: systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2016Pooled it
- Effects of a Nursing Intervention Based on a Solution-Focused Approach on Renal Transplant Recipients' Anxiety, Depression, and Quality of Life.Journal of nursing management · 2023Trial
- Is simplification of immunosuppressive medication a way to promote medication adherence of kidney transplant recipients? Findings from a randomized controlled trial.Transplant international : official journal of the European Society for Organ Transplantation · 2021Trial
- Feasibility of implementing mobile technology-delivered mental health treatment in routine adult sickle cell disease care.Translational behavioral medicine · 2020Trial
- Long-Term Mortality and Causes of Death After Kidney and Liver Transplantation: A Nationwide Population-Based Cohort Study in South Korea.Journal of clinical medicine · 2026Article
- Health Literacy and Early Physical Activity After Solid Organ Transplantation: A Prospective Observational Study.Clinical transplantation · 2026Observational
- From Assessment to Action: A Research Prototype for SIPAT-Based Multidomain Psychosocial Visualization and Prioritization in Lung Transplant Candidates.Journal of clinical medicine · 2026Article
- Psychosocial challenges with transplantation.Current opinion in pulmonary medicine · 2026Review
- Psychosocial Risk Factors and Outcomes Among Men and Women With Alcohol-Associated Liver Disease Undergoing Transplant Evaluation.Alcohol, clinical & experimental research · 2026Article
- State-Level Geographic Disparities in Liver Transplant Access: Waitlist Outcome Patterns.Journal of clinical medicine · 2026Article
- Global Epidemiology of Post-Transplant Lymphoproliferative Disorder (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT): A Systematic Review and Meta-Analysis of Incidence, Subtypes, Risk Factors, and Beyond.Journal of clinical medicine · 2026Review
- Patient-reported Outcome Measures in Solid Organ Transplant Recipients: Current use, Challenges, and Recommendations for Future use.Transplantation · 2026Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundDepression and anxiety are common mental health problems in transplant populations. There is mixed evidence concerning whether they increase morbidity and mortality risks after transplantation. If such associations exist, additional risk reduction strategies may be needed.
methodsFour bibliographic databases were searched from 1981 through September 2014 for studies prospectively examining whether depression or anxiety (determined with diagnostic evaluations or standardized symptom scales) affected risk for posttransplant mortality, graft loss, acute graft rejection, chronic rejection, cancer, infection, and rehospitalization.
resultsTwenty-seven studies (10 heart, total n = 1738; 6 liver, n = 1063; 5 kidney, n = 49515; 4 lung, n = 584; 1 pancreas, n = 80; 1 mixed recipient sample, n = 205) were identified. In each, depression and/or anxiety were typically measured before or early after transplantation. Follow-up for outcomes was a median of 5.8 years (range, 0.50-18.0). Depression increased the relative risk (RR) of mortality by 65% (RR, 1.65; 95% confidence interval [95% CI], 1.34-2.05; 20 studies). Meta-regression indicated that risk was stronger in studies that did (vs did not) control for potential confounders (P = .032). Risk was unaffected by type of transplant or other study characteristics. Depression increased death-censored graft loss risk (RR, 1.65; 95% CI, 1.21-2.26, 3 studies). Depression was not associated with other morbidities (each morbidity was assessed in 1-4 studies). Anxiety did not significantly increase mortality risk (RR, 1.39; 95% CI, 0.85-2.27, 6 studies) or morbidity risks (assessed in single studies).
conclusionsDepression increases risk for posttransplant mortality. Few studies considered morbidities; the depression-graft loss association suggests that linkages with morbidities deserve greater attention. Depression screening and treatment may be warranted, although whether these activities would reduce posttransplant mortality requires study.
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