Evidence map›Paper›PMID 26492010›Full record

ArticleNature chemistry2015

Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-peptide system.

Karla E Inostroza-Brito, Estelle Collin, Orit Siton-Mendelson, Katherine H Smith, Amàlia Monge-Marcet, Daniela S Ferreira, Raúl Pérez Rodríguez, Matilde Alonso, José Carlos Rodríguez-Cabello, Rui L Reis and 5 more

Abstract read
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In one paragraph

Article in Nature chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
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  5. Article
  6. Article
  7. Article
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  9. Article
  10. Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karla E Inostroza-BritoSchool of Engineering &Materials Science, Queen Mary University of London, London E1 4NS, UK.
Estelle CollinSchool of Engineering &Materials Science, Queen Mary University of London, London E1 4NS, UK.
Orit Siton-MendelsonDepartment of Chemical Engineering and the Ilze Katz, Institute for Nanoscale Science &Technology Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Katherine H SmithNanotechnology Platform, Parc Científic de Barcelona, Barcelona 08028, Spain.
Amàlia Monge-MarcetNanotechnology Platform, Parc Científic de Barcelona, Barcelona 08028, Spain.
Daniela S FerreiraSchool of Engineering &Materials Science, Queen Mary University of London, London E1 4NS, UK.
Raúl Pérez RodríguezNanotechnology Platform, Parc Científic de Barcelona, Barcelona 08028, Spain.
Matilde AlonsoBIOFORGE Group, University of Valladolid, CIBER-BBN, Valladolid 47011, Spain.
José Carlos Rodríguez-CabelloBIOFORGE Group, University of Valladolid, CIBER-BBN, Valladolid 47011, Spain.
Rui L Reis3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães 4805-017, Portugal.ORCID http://orcid.org/0000-0002-4295-6129
Francesc SaguésDepartament de Química Física, Universitat de Barcelona, Barcelona 08028, Spain.
Lorenzo BottoSchool of Engineering &Materials Science, Queen Mary University of London, London E1 4NS, UK.
Ronit BittonDepartment of Chemical Engineering and the Ilze Katz, Institute for Nanoscale Science &Technology Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Helena S AzevedoSchool of Engineering &Materials Science, Queen Mary University of London, London E1 4NS, UK.
Alvaro MataSchool of Engineering &Materials Science, Queen Mary University of London, London E1 4NS, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non-equilibrium for substantial periods of time. The system enables the formation of a robust membrane that displays controlled assembly and disassembly capabilities, adhesion and sealing to surfaces, self-healing and the capability to undergo morphogenesis into tubular structures with high spatiotemporal control. We use advanced microscopy along with turbidity and spectroscopic measurements to investigate the mechanism of assembly and its relation to the distinctive membrane architecture and the resulting dynamic properties. Using cell-culture experiments with endothelial and adipose-derived stem cells, we demonstrate the potential of this system to generate complex bioactive scaffolds for applications such as tissue engineering.

Indexed as

HumansHuman Umbilical Vein Endothelial CellsMicroscopy, Electron, ScanningMorphogenesisPeptidesProteinsTissue EngineeringTissue ScaffoldsPeptidesProteins

Identifiers

PMID26492010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.