ArticleNature chemistry2015
Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation.
Article in Nature chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Chalcogen bonding-directed photoresponsive helix from azo-fused H-bonded arylamide foldamers.Chemical science · 2026Article
- Design of an abiotic unimolecular three-helix bundle.Chemical science · 2025Article
- Innovative Self-Assembly of 15-Mer Chimeric α-Peptide-Oligourea Foldamers toward ClSmall science · 2024Article
- Stimuli-Responsive Oligourea Molecular Films.ACS applied materials & interfaces · 2024Article
- Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation.Nature communications · 2023Article
- C-Terminal-Modified Oligourea Foldamers as a Result of Terminal Methyl Ester Reactions under Alkaline Conditions.International journal of molecular sciences · 2023Article
- An abiotic, tetrameric, eight-helix bundle.Chemical science · 2023Article
- Review
- Crystallographic-Morphological Connections in Star Shaped Metal-Organic Frameworks.Journal of the American Chemical Society · 2022Article
- Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Directing the Morphology, Packing, and Properties of Chiral Metal-Organic Frameworks by Cation Exchange.Angewandte Chemie (International ed. in English) · 2022Article
- De novo design of discrete, stable 3Nature · 2022Article
- Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.Nature communications · 2022Article
- Discrete Stacked Dimers of Aromatic Oligoamide Helices.Angewandte Chemie (International ed. in English) · 2022Article
- Controlling the conformational stability of coiled-coil peptides with a single stereogenic center of a peripheral β-amino acid residue.RSC advances · 2022Article
- Potential Foldamers Based on anOrganic letters · 2021Article
- Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity.Science advances · 2021Article
- Large-Amplitude Conformational Changes in Self-Assembled Multi-Stranded Aromatic Sheets.Angewandte Chemie (International ed. in English) · 2021Article
- Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials.Nature communications · 2021Article
- Analysis of folded structure and folding thermodynamics in heterogeneous-backbone proteomimetics.Methods in enzymology · 2021Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The design and construction of biomimetic self-assembling systems is a challenging yet potentially highly rewarding endeavour that contributes to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of biological processes. Significant progress has been achieved by engineering self-assembling DNA-, protein- and peptide-based building units. However, the design of entirely new, completely non-natural folded architectures that resemble biopolymers ('foldamers') and have the ability to self-assemble into atomically precise nanostructures in aqueous conditions has proved exceptionally challenging. Here we report the modular design, formation and structural elucidation at the atomic level of a series of diverse quaternary arrangements formed by the self-assembly of short amphiphilic α-helicomimetic foldamers that bear proteinaceous side chains. We show that the final quaternary assembly can be controlled at the sequence level, which permits the programmed formation of either discrete helical bundles that contain isolated cavities or pH-responsive water-filled channels with controllable pore diameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.