ArticleAdvances in pediatric research2015
Ethanol, Neurodevelopment, Infant and Child Health (ENRICH) prospective cohort: Study design considerations.
Article in Advances in pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Magnetoencephalography and the infant brain.NeuroImage · 2019Pooled it
- The association between prenatal alcohol exposure and protein expression in human placenta.Birth defects research · 2019Trial
- Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- Impact of low-level prenatal alcohol exposure and maternal stress on autonomic regulation.Pediatric research · 2024Article
- Effects of prenatal opioid and alcohol exposures on immune and serotonin factors in human placenta.Experimental neurology · 2022Article
- Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome.Scientific reports · 2022Article
- Severity of neonatal opioid withdrawal syndrome with prenatal exposure to serotonin reuptake inhibitors.Pediatric research · 2022Article
- Prevalence of marijuana use in pregnant women with concurrent opioid use disorder or alcohol use in pregnancy.Addiction science & clinical practice · 2022Article
- Maternal verbal scaffolding: association with higher language skills for 20-month-old children with prenatal polysubstance exposure.Early human development · 2021Article
- Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.Adversity and resilience science · 2020Article
- Disparities in breastfeeding outcomes among women with opioid use disorder.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
- Association between prenatal opioid exposure, neonatal opioid withdrawal syndrome, and neurodevelopmental and behavioral outcomes at 5-8 months of age.Early human development · 2019Article
- Role of caregiver-reported outcomes in identification of children with prenatal alcohol exposure during the first year of life.Pediatric research · 2018Article
- Prevalence of alcohol use in pregnant women with substance use disorder.Drug and alcohol dependence · 2018Article
- Dietary Intake Among Opioid- and Alcohol-Using Pregnant Women.Substance use & misuse · 2018Article
- Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol.NeuroImage. Clinical · 2018Article
- The effect of prenatal substance use and maternal contingent responsiveness on infant affect.Early human development · 2017Article
- Hepatitis C Cascade of Care Among Pregnant Women on Opioid Agonist Pharmacotherapy Attending a Comprehensive Prenatal Program.Maternal and child health journal · 2017Article
- Stability of Phosphatidylethanol in Dry Blood Spot Cards.Alcohol and alcoholism (Oxford, Oxfordshire) · 2016Article
- Effects of medications for opioid use disorder (MOUD) on fetal brain and cranial measurements.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhile intervention is the leading factor in reducing long-term disabilities in children with fetal alcohol spectrum disorder (FASD), early identification of children affected by prenatal alcohol exposure (PAE) remains challenging. Deficits in higher-order cognitive domains (e.g. executive function) might be more specific to FASD than global neurodevelopmental tests, yet these functions are not developed in very young children. Measures of early sensorimotor development may provide early indications of atypical brain development during the first two years of life.
methodsThis paper describes the novel methodology of the Ethanol, Neurodevelopment, Infant and Child Health (ENRICH) prospective cohort study of 120 maternal-infant pairs with a goal to identify early indices of functional brain impairment associated with PAE. The cohort is established by recruiting women early in pregnancy and classifying them into one of three study groups: patients on opioid-maintenance therapy who consume alcohol during pregnancy (Group 1), patients on opioid-maintenance therapy who abstain from alcohol during pregnancy (Group 2), and healthy controls (Group 3). After the initial prenatal assessment (Visit 1), patients are followed to Visit 2 occurring at delivery, and two comprehensive assessments of children at six (Visit 3) and 20 months (Visit 4) of age. ENRICH recruitment started in November 2013 and 87 women were recruited during the first year. During Year 1, the biospecimen (maternal whole blood, serum, urine, dry blood spots of a newborn) collection rate was 100% at Visit 1, and 97.6% for those who completed Visit 2. DISCUSSION: The tiered screening approach, evaluation of confounders, neurocognitive and magneto-/electro-encephalography (MEG/EEG) outcomes, and ethical considerations are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.