ArticleBioelectronic medicine2015
Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function.
Article in Bioelectronic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04120545 (Effectiveness of Microcurrents Therapy in Overactive Bladder), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Microcurrents Therapy in Overactive Bladder : Controlled and Randomized Triple Blind Clinical Trial
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Efficacy differences between SNM and various peripheral nerve electrical stimulation modalities for NLUTD: a Bayesian network meta-analysis.Frontiers in neurology · 2026Pooled it
- Transcutaneous electrical stimulation of somatic afferent nerves in the foot relieved symptoms related to postoperative bladder spasms.BMC urology · 2017Trial
- Article
- Transcutaneous tibial neuromodulation, is the future of neuromodulation here?World journal of urology · 2026Review
- Reframing loss of efficacy in sacral neuromodulation: a neurofunctional service model for coloproctology.Techniques in coloproctology · 2026Article
- Precise control of tibial nerve stimulation for bladder regulation via evoked compound action potential feedback mechanisms.Nature communications · 2025Article
- Tibial nerve stimulation increases vaginal blood perfusion and bone mineral density and yield load in ovariectomized rat menopause model.International urogynecology journal · 2022Article
- Action Understanding Promoted by Interoception in Children: A Developmental Model.Frontiers in psychology · 2022Review
- A Microclip Peripheral Nerve Interface (μcPNI) for Bioelectronic Interfacing with Small Nerves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Wireless and battery-free platforms for collection of biosignals.Biosensors & bioelectronics · 2021Review
- Functional segregation within the pelvic nerve of male rats: a meso- and microscopic analysis.Journal of anatomy · 2020Article
- Article
- Effects of electroacupuncture on bladder and bowel function in patients with transverse myelitis: a prospective observational study.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2018Observational
- Non-invasive electromyographic estimation of motor unit number in the external anal sphincter of the rat.Neurourology and urodynamics · 2018Article
- Novel Neurostimulation of Autonomic Pelvic Nerves Overcomes Bladder-Sphincter Dyssynergia.Frontiers in neuroscience · 2018Article
- The role of the neurometer CPT/C in sacral neuromodulation.Turkish journal of urology · 2018Article
- Toward Bioelectronic Medicine-Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Electrical stimulation structurally affects the tissues of the rectum and anus of nulliparous rats.Journal of anatomy · 2017Article
- Towards Closed-Loop Neuromodulation: A Wireless Miniaturized Neural Implant SoC.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neuromodulation elicited by electrical stimulation of peripheral or spinal nerves is a U.S. Food and Drug Administered (FDA)-approved therapy for treating disorders of the pelvic viscera, including urinary urgency, urgency-frequency, nonobstructive urinary retention and fecal incontinence. The technique is also being tested experimentally for its efficacy in treating interstitial cystitis, chronic constipation and pelvic pain. The goal of neuromodulation is to suppress abnormal visceral sensations and involuntary reflexes and restore voluntary control. Although detailed mechanisms underlying the effects of neuromodulation are still to be elucidated, it is generally believed that effects are due to stimulation of action potentials in somatic afferent nerves. Afferent nerves project to the lumbosacral spinal cord, where they release excitatory neurotransmitters that activate ascending pathways to the brain or spinal circuits that modulate visceral sensory and involuntary motor mechanisms. Studies in animals revealed that different types of neuromodulation (for example, stimulation of a sacral spinal root, pudendal nerve or posterior tibial nerve) act by releasing different inhibitory and excitatory neurotransmitters in the central nervous system. In addition, certain types of neuromodulation inhibit visceral smooth muscle by initiating reflex firing in peripheral autonomic nerves or excite striated sphincter muscles by initiating reflex firing in somatic efferent nerves. This report will provide a brief summary of (a) neural control of the lower urinary tract and distal bowel, (b) clinical use of neuromodulation in the treatment of bladder and bowel dysfunctions,
Identifiers
26491706PMC4610375W2111290077What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.