Evidence map›Paper›PMID 26491679›Full record

ArticleBioMed research international2015

Influence of Ionizing Radiation on Two Generations of Cochlear Implants.

Nicolas Guevara, Anaïs Gérard, Jeanne Dupré, Delphine Goursonnet, Michel Hoen, Dan Gnansia, Gaëlle Angellier, Juliette Thariat

Abstract read
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Challenges of Hearing Rehabilitation after Radiation and Chemotherapy.Journal of neurological surgery. Part B, Skull base · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolas GuevaraDepartment of Head and Neck Surgery, CHU Nice, 06100 Nice, France.
Anaïs GérardDepartment of Radiation Oncology/IBDC CNRS UMR 6543, Cancer Center Antoine-Lacassagne, University Nice Sophia-Antipolis, 06189 Nice, France.
Jeanne DupréClinical and Scientific Research Department, Oticon Medical-Neurelec, 06220 Vallauris, France.
Delphine GoursonnetClinical and Scientific Research Department, Oticon Medical-Neurelec, 06220 Vallauris, France.
Michel HoenClinical and Scientific Research Department, Oticon Medical-Neurelec, 06220 Vallauris, France.
Dan GnansiaClinical and Scientific Research Department, Oticon Medical-Neurelec, 06220 Vallauris, France.
Gaëlle AngellierDepartment of Head and Neck Surgery, CHU Nice, 06100 Nice, France.
Juliette ThariatDepartment of Head and Neck Surgery, CHU Nice, 06100 Nice, France ; Department of Radiation Oncology/IBDC CNRS UMR 6543, Cancer Center Antoine-Lacassagne, University Nice Sophia-Antipolis, 06189 Nice, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the present study was to test the behavior of two different generations of cochlear implant systems subjected to a clinical radiotherapy scheme and to determine the maximal acceptable cumulative radiation levels at which the devices show out-of-specification behaviors. Using stereotactic irradiation (Cyberknife, 6 MV photon beam), three Digisonic SP and three Neuro devices were submitted to 5 Gy doses that cumulated to 60 Gy (12 sessions) and 80 Gy (16 sessions), respectively. A follow-up series of irradiation was then applied, in which Digisonic SP devices received two additional fractions of 50 Gy each, cumulating to 160 Gy, and Neuro devices three additional fractions of 20, 40, and 150 Gy, cumulating to 290 Gy. Output current values were monitored during the treatment. At clinical doses, with 60 or 80 Gy cumulative radiation exposure, no single measurement showed more than 10% divergence from the reference measure. The cochlear implants tested in this study showed high resistance to clinically relevant cumulative radiation doses and showed no out-of-bounds behavior up to cumulative doses of 140 or 160 Gy. These observations suggest that cochlear implant users can undergo radiotherapy up to cumulative doses well above those currently used in clinical situations without risk of failure.

Indexed as

Cochlear ImplantsMaterials TestingRadiation, IonizingHumans

Identifiers

PMID26491679
PMCPMC4600872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.